Novel neonicotinoid insecticide cycloxaprid exhibits sublethal toxicity to honeybee (Apis mellifera L.) workers by disturbing olfactory sensitivity and energy metabolism.

The risk of neonicotinoid insecticides to honeybees is a global issue. Cycloxaprid (CYC) is a novel neonicotinoid insecticide with outstanding activities, good safety profiles, and no cross-resistance with other neonicotinoids. Information on the environmental risks of CYC is limited, especially its effects on honeybees.

Layer symmetry and irradiation dominate the oxidation capability of birnessite on biogenic isoprene.

The climate-active gas isoprene (CH) is one of the most abundant biogenic volatile organic compounds (VOCs). Soil is one of the significant sinks for isoprene, yet the role played by the naturally abundant birnessite in the soil surface layer during the oxidation of isoprene remains largely unknown. This study investigates the reactions of isoprene with triclinic and hexagonal birnessite on the Earth's surface environments.

Global decline in microbial-derived carbon stocks with climate warming and its future projections.

Soil organic carbon (SOC) represents the largest terrestrial pool of organic carbon and is indispensable for mitigating climate change and sustaining soil fertility. As a major component of stable SOC, microbial-derived carbon (MDC) accounts for approximately half of the total SOC and has repercussions on climate feedback. However, our understanding of the spatial and temporal dynamics of MDC stocks is limited, hindering assessments of the long-term impacts of global warming on persistent SOC sequestration in the soil‒atmosphere carbon cycle.

Linear polyubiquitylation of Gli protein regulates its protein stability and facilitates tumor growth in colorectal cancer.

The linear ubiquitin chain assembly complex (LUBAC) mediates the linear ubiquitination of various proteins and is involved in NF-κB signaling and immune regulation. However, the function and mechanism of linear ubiquitination in regulating oncogenic signaling and tumor growth have remained poorly understood. Herein, we identified Gli proteins, key transcription factors in the Hedgehog (Hh) signaling pathway, as novel substrates of LUBAC.

Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer.

Purpose: The hyperactivation of epidermal growth factor receptor (EGFR) plays a crucial role in non-small cell lung cancer (NSCLC). Hedgehog (Hh) signaling has been implicated in the tumorigenesis and progression of various cancers, however, its function in NSCLC cells remains controversial. Herein, we present a novel finding that challenges the current understanding of Hh signaling in tumor growth.

Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth.

Hedgehog (Hh) signaling plays a critical role in embryogenesis and tissue homeostasis, and its deregulation has been associated with tumor growth. The tumor suppressor SuFu inhibits Hh signaling by preventing the nuclear translocation of Gli and suppressing cell proliferation. Regulation of SuFu activity and stability is key to controlling Hh signaling.