Publications by authors named "Aidar M Murzakaev"
Article Synopsis
- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
Article Synopsis
- The study examines how the acidic environment of tumors affects the delivery of magnetic nanoparticles (MNPs) modified with a peptide that responds to low pH levels.
- Researchers found that these pHLIP-conjugated MNPs were more effective at targeting cancer cells in acidic conditions (pH 6.4) compared to neutral (pH 7.2).
- Results indicated a correlation between the acidity of the tumor microenvironment and the accumulation of MNPs, suggesting the potential for personalized treatment strategies based on tumor pH profiles.
L-Lysine-modified FeO nanoparticles for magnetic cell labeling.
Alexander M Demin Alexander V Mekhaev Oleg F Kandarakov Vladimir I Popenko Olga G Leonova Aidar M Murzakaev
Colloids Surf B Biointerfaces
June 2020
The efficiency of magnetic labeling with L-Lys-modified FeO magnetic nanoparticles (MNPs) and the stability of magnetization of rat adipose-derived mesenchymal stem cells, lineage-negative (Lin(-)) hematopoietic progenitor cells from mouse bone marrow and human leukemia K562 cells were studied. For this purpose, covalent modification of MNPs with 3-aminopropylsilane and N-di-Fmoc-L-lysine followed by removal of N-protecting groups was carried out. Since the degree of hydroxylation of the surface of the starting nanoparticles plays a crucial role in the silanization reaction and the possibility of obtaining stable colloidal solutions.
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