Publications by authors named "Aidan Richards"
Article Synopsis
- Establishing effective biomarkers for diagnosing and predicting multiple sclerosis (MS) is difficult when relying on single biomarkers, leading researchers to explore multi-biomarker combinations.
- In a study involving 77 MS patients and 80 with other neurological disorders, 24 fluid biomarkers were examined, showing that combination models significantly outperformed single biomarker predictions.
- The best diagnostic combination achieved an area under the curve of 0.97, while optimal predictions for relapse timing and disability milestones greatly improved, indicating the potential of multi-biomarker approaches in MS management.
Background: People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear.
Objective: To report COVID-19 rates in pwMS according to vaccine serology.
Methods: PwMS with available (1) serology 2-12 weeks following COVID-19 vaccine 2 and/or vaccine 3 and (2) clinical data on COVID-19 infection/hospitalisation were included.
Background: People with MS treated with anti-CD20 therapies and fingolimod often have attenuated responses to initial COVID-19 vaccination. However, uncertainties remain about the benefit of a 3rd (booster) COVID-19 vaccine in this group.
Methods: PwMS without a detectable IgG response following COVID-19 vaccines 1&2 were invited to participate.