Publications by authors named "Aidan O'Connor"
Objectives: Heightened systemic inflammation is common in obese individuals and persons with HIV (PWH) and is independently associated with an increased risk of cardiovascular diseases (CVDs). We investigated the combined effect of central obesity, a surrogate measure of visceral fat and HIV on circulating levels of inflammatory cytokines among Kenyan adults.
Design: A cross-sectional study.
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.
Antimicrob Agents Chemother
March 2021
Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry. We hypothesize that repurposing of combinations of orally administered approved drugs provides effective suppression of arenaviruses.
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- Systemic inflammation is a key predictor of cardiovascular disease (CVD) risk, showing a 2-fold increase among individuals living with HIV (PLHIV).
- A study in Kenya measured inflammatory markers in both PLHIV and HIV-negative individuals, finding significantly higher levels of markers like IL-6 and TNF-α in those with HIV, regardless of other CVD risk factors.
- The findings suggest that even virally suppressed PLHIV have elevated inflammation levels, indicating the need for further research to explore the predictive value of these markers for future CVD events and potential treatments.