Publications by authors named "Aidan Herbert"
Article Synopsis
- - Treatment-induced ototoxicity from chemotherapy or antibiotics can lead to significant hearing loss, making early intervention crucial; this study explores a local delivery method to the inner ear using crosslinked hybrid nanoparticles (cHy-NPs) in a thermoresponsive hydrogel to combat this issue.
- - The study focuses on two therapeutic agents, Flunarizine (a calcium channel blocker) and Honokiol (an antioxidant), co-encapsulated in the nanoparticles to provide cytoprotection against cisplatin-induced toxicity in specific cell models and in living zebrafish.
- - The findings demonstrate that the combination of Flunarizine and Honokiol within the nanoparticles enhances their protective effects; the nanoparticles were successfully synthesized with a high drug
Article Synopsis
- - This research focuses on how the surface properties of copper oxide-decorated carbon nanofiber membranes affect their efficiency in membrane distillation (MD) for desalination.
- - The study created membranes using a phase inversion method, finding that adding 1 wt % of copper oxide and carbon nanofibers significantly improved water vapor flux by 64% and achieved over 99.8% salt rejection due to changes in chemical structure and porosity.
- - To analyze and predict the membranes' performance, the researchers applied machine learning techniques on electron microscopy images to map pore distribution and used a statistical model to forecast performance over time based on MD test data.
In the past several decades, polymeric microparticles (MPs) have emerged as viable solutions to address the limitations of standard pharmaceuticals and their corresponding delivery methods. While there are many preclinical studies that utilize polymeric MPs as a delivery vehicle, there are limited FDA-approved products. One potential barrier to the clinical translation of these technologies is a lack of understanding with regard to the manufacturing process, hindering batch scale-up.
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