Publications by authors named "Aida Sanchez-Garcia"
Article Synopsis
- This study aims to quickly and accurately detect the Y132F ERG11p mutation in Candida parapsilosis isolates and to analyze genetic diversity among these isolates for better tracking of fluconazole resistance.!* -
- The research involved 223 isolates from patients across 20 hospitals in Spain and Italy, using newly optimized PCR methods that require no DNA extraction and provide results in as little as 1.5 hours.!* -
- The findings confirm both PCR methods have 100% specificity and sensitivity, with Scheme 1 showing greater genetic diversity compared to Scheme 2, suggesting the use of specific microsatellite markers for better genotyping of resistant strains.!*
Article Synopsis
- CP-Eco isolates are a type of bacteria that can spread antibiotic resistance genes quickly and lead to infections that are hard to treat. This study aimed to analyze these isolates from Spain to learn more about their resistance and genetic makeup.
- A total of 90 isolates from various hospitals in Spain were examined for their antibiotic susceptibility and genetic characteristics. Notably, a common strain (ST131) was identified, with many isolates demonstrating resistance to multiple antibiotic groups.
- The research found that a significant number of isolates had complex genetic traits that contribute to their resistance, with some exhibiting virulence genes. The study underscores the concern of CP-Eco's ability to spread antibiotic resistance in both community and hospital settings.
Background: Fluconazole-resistant Candida parapsilosis is a matter of concern.
Objectives: To describe fluconazole-resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole-resistance profile associated with ERG11p substitutions.
Article Synopsis
- The study builds on findings from the CANDIMAD study (2019-2021) regarding antifungal resistance in Madrid, revealing trends of increased fluconazole resistance in 2022 among isolates from blood cultures and intra-abdominal samples.
- A total of 766 isolates were collected, with a notable rise in fluconazole resistance (12.0% overall, 16.0% in blood cultures), largely attributed to specific resistant clones, while resistance to other antifungals remained low.
- The data indicates a concerning spread of fluconazole-resistant genotypes in Madrid, with up to 7 out of 16 hospitals reporting affected cases, highlighting the need for vigilance in antifungal treatment strategies.
Objectives: Antifungal susceptibility testing is mostly conducted on blood-cultured Candida spp isolates. Because the intra-abdominal cavity has been highlighted as a hidden echinocandin-resistant C. glabrata reservoir, we assessed whether testing sequential isolates from a given patient might increase the chances of detecting antifungal resistance.
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View Article and Find Full Text PDFBackground: Candidaemia and invasive candidiasis are typically hospital-acquired. Genotyping isolates from patients admitted to different hospitals may be helpful in tracking clones spreading across hospitals, especially those showing antifungal resistance.
Methods: We characterized clusters by studying isolates (, = 1041; , = 354, and , = 125) from blood cultures (53.
Objectives: We prospectively monitored the epidemiology and antifungal susceptibility of Candida spp. from blood cultures and intra-abdominal samples in patients admitted to hospitals in the Madrid area.
Methods: Between 2019 and 2021, we prospectively collected incident isolates [one per species, patient and compartment (blood cultures versus intra-abdominal samples)] from patients admitted to any of 16 hospitals located in Madrid.
We have been monitoring the antifungal resistance in Candida parapsilosis isolates collected from inpatients at Madrid metropolitan area hospitals for the last 3 years. The study aimed to elucidate the presence of fluconazole-resistant C. parapsilosis genotypes in Madrid.
View Article and Find Full Text PDFEndocarditis, A Clinical Case Not Previously Described.
Eur J Case Rep Intern Med
February 2019
Objective: To review infections by
Materials And Methods: A 79-year-old male patient, with a chronic aortic valve biological prosthesis, presented to hospital because of fever. First examinations were normal. However, 72 hours later was isolated in blood cultures, and so meropenem was prescribed.