Publications by authors named "Aida Larti"
Background: Among different forms of de novo focal segmental glomerulosclerosis (FSGS), which can develop after kidney transplantation (KTx), collapsing glomerulopathy (CG) is the least frequent variant, but it is associated with the most severe form of nephrotic syndrome, histological findings of important vascular damage, and a 50% risk of graft loss. Here, we report two cases of de novo post-transplant CG.
Clinical Presentation: A 64-year-old White man developed proteinuria and worsening of renal function 5 years after KTx.
During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after a contact with her positive mother.
View Article and Find Full Text PDFObjective: To report the development of the first robot-assisted kidney transplantation (RAKT) programme from deceased donors, examining technical feasibility and early perioperative and functional outcomes at a referral academic centre.
Patients And Methods: A RAKT programme was developed in 2016 at our institution following structured modular training. Specific inclusion/exclusion criteria for both living and deceased donors were set.
Article Synopsis
- * Results showed that the everolimus group had a significantly lower rate of delayed graft function (DGF) and better one-year graft survival rates, along with lower CsA dosage and higher kidney function (eGFR) at one year.
- * While everolimus patients had some slight disadvantages, such as more proteinuria and slightly lower hemoglobin levels, the overall findings suggest that everolimus therapy could be more beneficial than EC-MPS therapy in terms
Article Synopsis
- Renal transplant recipients (RTRs) have a higher risk of cardiovascular issues, prompting a study to evaluate reticulated platelets (RP), platelet reactivity, and von Willebrand factor (vWF) levels in these patients.
- The study involved 150 RTRs (some on acetylsalicylic acid, ASA, and some not) and 60 healthy controls, measuring RP percentages, platelet function via aggregometry, and vWF levels.
- Findings indicated that RTRs had significantly higher RP and vWF levels compared to controls, with those not on ASA showing greater platelet reactivity, suggesting increased platelet turnover and cardiovascular risk in RTRs.
Article Synopsis
- The study investigates proteinuria linked to mTOR inhibitors, specifically Everolimus, in renal transplant patients, highlighting a lack of understanding about its causes and mechanisms.
- Among the patients treated with Everolimus, 39% developed significant proteinuria, with certain urinary proteins correlating with the degree of protein loss.
- Proteomic analysis revealed significant increases in various urinary proteins associated with kidney damage when using Everolimus, indicating that the treatment can lead to serious renal alterations visible in urine tests.