Neuroprotective and inflammatory biomarkers in pediatric drug-resistant epilepsy: Interplay between GDNF, IL-1β and vitamin D 25-OH.

Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell line- derived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy.

Association between working memory impairment and activities of daily living in post-stroke patients.

Aim Stroke is one of the leading causes of adult disability and functional impairment worldwide. Cognitive impairments including memory dysfunction are common after stroke and may have a negative impact to the functional status and activities of daily living (ADL). The study aimed to determine the impact of working memory impairment after stroke on ADL.