Objective: TH17 cells have involved in the pathogenesis of several autoimmune diseases including systemic sclerosis (SSc). The aim of our study was to investigate an association of IL-17A, IL-17F, IL-21, IL-23R and STAT3 genes with SSc susceptibility, and clinical and immunological phenotypes.
Patients And Methods: The case-control study included 136 patients suffering from SSc and 317 healthy controls of the Algerian population.