Novel fluorescent nanoplatform for all-in-one sensing and removal of acrolein: An ultrasensitive probe to evaluate its removal efficiency.

As a highly toxic aldehyde, acrolein is widely found in diet and environment, and can be produced endogenously, posing a serious threat to human health. Herein, we designed a novel fluorescent nanoplatform integrating carbon dots‑manganese dioxide (CDs-MnO) and glutathione (GSH) for all-in-one sensing and removal of acrolein. By converting Mn to free Mn, GSH inhibited the inner filter effect (IFE) of MnO nanosheets, and the Michael addition of acrolein with GSH inhibited the GSH-induced Mn conversion, forming an "off-on-off" fluorescence response of CDs.

Aspergichromones A-E, Five Chromone Derivatives with Complicated Polycyclic Architecture from .

Five unprecedented chromone derivatives involving a 6/6/5/5/5/6 hexacyclic scaffold (, ), 6/6/5/6/6/6/6 heptacyclic scaffold (), and 6/6/6/5/5/6 hexacyclic scaffold (, ) were obtained from the fungus NCC0415. Their structures were identified using comprehensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Except for , the other compounds, especially the 6/6/6/5/5/6 hexacyclic derivatives ( and ), exhibited potent inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitory activities.

Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii.

With the aim of finding more potential inhibitors against NADH-fumarate reductase (specific target for treating helminthiasis and cancer) from natural resources, Talaromyces wortmannii was treated with the epigenome regulatory agent suberoylanilide hydroxamic acid, which resulted in the isolation of four new wortmannilactones derivatives (wortmannilactones I-L, 1-4). The structures of these new compounds were elucidated based on IR, HRESIMS and NMR spectroscopic data analyses. These four new compounds showed potent inhibitory activity against NADH-fumarate reductase with the IC values ranging from 0.

Three novel members of angucycline group from Streptomyces sp. N05WA963.

Three novel members of angucycline family named N05WA963A (1), B (2) and D (4), together with a new anthracycline named N05WA963C (3) were isolated from the culture broth of Streptomyces sp. N05WA963. The structures were elucidated on the basis of comprehensive spectral data analysis.