Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma.

Long noncoding RNA SET-binding factor 2 (SBF2) antisense RNA 1 (AS1) is associated with the growth and metastasis of multiple cancer types, but its biological roles in serous ovarian carcinoma (SOC) remain unclear. In this study, the aberrant upregulation of SBF2-AS1 is detected in SOC after analysis of differentially expressed genes between SOC tissues and normal fallopian tubes from the public Gene Expression Omnibus (GEO) database. We determine that knockdown of SBF2-AS1 inhibits SOC cell proliferation and invasion by sponging miR-338-3p.

MiR-200a promotes proliferation of cervical cancer cells by regulating HIF-1α/VEGF signaling pathway.

Purpose: To explore the biological function of micro ribonucleic acid (miR)-200a in cervical cancer (CC).

Methods: HeLa cells were transfected with miR-200a inhibitor or negative control (NC). Next, the effects of miR-200a down-regulation on the proliferation of CC cells were detected via methyl thiazolyl tetrazolium (MTT) assay and colony formation assay.