Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2 Pathway in A549 Cells.

Acute lung injury (ALI) is a complicated and severe lung disease, which is often characterized by acute inflammation. Poliumoside (POL), acteoside (ACT) and forsythiaside B (FTB) are phenylethanoid glycosides (PGs) with strong antioxidant, anti-inflammatory, and anti-apoptotic properties, which are extracted from (CK). The aim of this study was to investigate the protective effects of POL, ACT, and FTB against TNF-α-induced damage using an ALI cell model and explore their potential mechanisms.

New glycosylsphingolipids from L.

In clinical, L. was often substitute for to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of L.

[Interaction of phenylethanoid glycosides and calf thymus DNA].

In physiological condition, the interaction of acteoside and forsythoside B with calf thymus DNA using neutral red (NR) as a fluorescence probe were investigated by fluorescence, UV-visible spectrophotometry, viscosity, DNA melting techniques, and molecular docking. It is observed that acteoside and forsythoside B can react with DNA. The major mode of recognition between drug and DNA is groove binding by hydrogen bonds, and the interaction of acteoside with DNA is stronger than that of forsythoside B.

Structure-activity relationships of antioxidant activity in vitro about flavonoids isolated from Pyrethrum tatsienense.

Aim: Antioxidant activity is one of the important indexes for estimating medicinal value for the traditional Chinese medicine. The aim of this study is to investigate the antioxidant activity of 11 flavonoids mainly revealing luteolin as mother nucleus isolated from Pyrethrum tatsienense.

Materials And Methods: The antioxidant activity of 11 flavonoids was measured in vitro using the classical 1,1-diphenyl-2-picrylhydrazyl removal method.

Diterpenoid alkaloids and flavonoids from Delphinium trichophorum.

Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.

Phenylethanoid glycosides from the stems of Callicarpa peii (hemostatic drug).

Two new trisaccharide intermediates of phenylethanoid glycosides, peiioside A(1)/A(2) (1a/1b) and peiioside B (2), were isolated from the n-BuOH fraction of MeOH extract of the stems of Callicarpa peii H.T. Chang, together with five biogenetic relevant known compounds 3-7.

catena-Poly[[[pentaaquaeuropium(III)]-μ-5-sulfonatoisophthalato-κO,O:O,O] 4,4'-bipyridine N,N'-dioxide hemisolvate trihydrate].

In the crystal structure of the title compound, {[Eu(C(8)H(3)O(7)S)(H(2)O)(5)]·0.5C(10)H(8)N(2)O(2)·3H(2)O}(n), the Eu(III) coordination polymer displays a ribbon motif as the 5-sulfoisopthalate anion uses one of carboxyl -CO(2) units to chelate to a Eu atom and the other to bind to other two Eu atoms; the sulfonyl -SO(3) unit is not involved in coordination. Adjacent ribbons are linked by O-H⋯O hydrogen bonds, generating a three-dimensional network.

Bis{(1-methyl-imidazol-2-ylmeth-yl)[2-(2-pyridyl)eth-yl]amine-κN,N',N''}zinc(II) bis-(hexa-fluoridophosphate).

Two tridentate N-heterocyclic ligands chelate the Zn(II) atom in the title compound, [Zn(C(12)H(16)N(4))(2)](PF(6))(2), conferring a fac-octa-hedral geometry. The Zn(II) atom lies on a center of inversion. The cation is linked to the anion by an N-H⋯F hydrogen bond.

[Preparation and spectra of the complexes of the first series transition metals with diphenic acid].

The ligand diphenic acid has been synthesized and the corresponding complexes of transition metal Co, Ni and Mn with diphenic acid have been prepared and characterized by the elementary analysis, IR spectra and ultraviolet-visible spectra. The results of IR show that the vas and vs of -CO2- in the complexes are lower than those of ligand diphenic acid, which can be explained by the coordinating between metal and ligand. In addition, compared with the complex IR spectra, the IR spectra of ligand became complicated due to the ligand polymerization through hydrogen bond.