Efficacy and Safety of the Chinese Herbal Compound TJAOA101 in Treating Diminished Ovarian Reserve: A Protocol for Multicenter, Prospective, and Pre-Post Study.

Objective: Diminished ovarian reserve (DOR) can lead to early menopause, poor fecundity, and an increased risk of disorders such as osteoporosis, cardiovascular disease, and cognitive impairment, seriously affecting the physical and mental health of women. There is still no safe and effective strategy or method to combat DOR. We have developed a novel Chinese herbal formula, Tongji anti-ovarian aging 101 (TJAOA101), to treat DOR.

[Protective effects of caloric restriction on ovarian function].

Objective: To study the protective effects on ovarian function by caloric restriction (CR) and its mechanism.

Methods: Thirty female C57BL/6 mice of 8 weeks old were randomly divided into two groups, including ad libitum (AL) group and caloric restriction (CR) group. The general situation and ovarian function of those mice were compared and evaluated.

[Expression and significance of Smad2/3 and HPV16 E7 in cervical intraepithelial neoplasia and cervical carcinoma].

Background & Objective: Smad proteins are downstream signal proteins of the transforming growth factor-beta (TGF-beta) superfamily, which are intimately related to the genesis of many human carcinomas. Human papillomavirus (HPV) is an important carcinogenic agent of cervical cancer. However, their relationship in the genesis of cervical cancer is unclear.

[Reversal effect of antisense RNA targeting human papillomavirus 16 (HPV16) E6E7 on malignancy of human cervical cancer cell line SiHa].

Background & Objective: The ubiquitinated degradation of p53 can be induced by human papillomavirus type 16 (HPV16) early gene 6 (E6); the phosphorylated inactivation of pRb can be induced by HPV16 E7. They are closely associated with the carcinogenesis and progression of cervical cancer. This study was to investigate the effects of HPV16 E6E7 antisense RNA on the expression of oncogene E6 and E7 and apoptosis of human cervical cancer cell line SiHa harboring HPV16 genome.