Meta-analysis of efficacy and safety of pembrolizumab for the treatment of advanced or recurrent cervical cancer.

Background: This meta-analysis seeks to assess the efficacy and safety of pembrolizumab in individuals with advanced or recurrent cervical cancer.

Methods: Databases from PubMed, Embase, and the Cochrane Library were all thoroughly searched for pertinent research. Outcomes include complete response (CR), partial response (PR), stable disease (SD), disease progression (PD), overall response rate (ORR), disease control rate (DCR), median progression-free survival (mPFS), median overall survival (mOS), and adverse events (AEs) were retrieved for further analysis.

[KMT2A Activates Akt/mTOR Signaling Pathway Through LncRNA-HOTAIR to Influence the Biological Behavior of AML Cells].

Objective: To investigate the expression of lysine methyltransferase 2A (KMT2A) in acute myeloid leukemia (AML) cells and its molecular mechanism affecting the proliferation of AML cells.

Methods: Co-immunoprecipitation assay was used to detect the binding of KMT2A to long non-coding RNA-HOX transcript antisense RNA (lncRNA-HOTAIR). AML cell proliferation was detected by 5-ethynyl-2'-deoxyuridine (EdU) assay.

Identification and Verification of Biomarker in Clear Cell Renal Cell Carcinoma via Bioinformatics and Neural Network Model.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, which represents the 9th most frequently diagnosed cancer. However, the molecular mechanism of occurrence and development of ccRCC is indistinct. Therefore, the research aims to identify the hub biomarkers of ccRCC using numerous bioinformatics tools and functional experiments.

Progress in the correlation between PTPN12 gene expression and human tumors.

Background: The global morbidity of cancer is rising rapidly. Despite advances in molecular biology, immunology, and cytotoxic and immune-anticancer therapies, cancer remains a major cause of death worldwide. Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is a new member of the cytoplasmic protein tyrosine phosphatase family, isolated from a cDNA library of adult colon tissue.

Research progress on advanced renal cell carcinoma.

Renal cell carcinoma (RCC) is a malignant tumor and the third most common urinary disease. It was estimated that RCC affected over 350,000 individuals in 2013, and there are nearly 140,000 deaths annually due to this disease. The initial masses in RCC patients are mostly confined to a single organ.

The complete plastid genome sequence of (Plantaginaceae): an endangered species endemic to The Himalayas regions.

(Pennell) Hong, an endangered perennial species, is endemic to the Eastern Himalayas and Hengduan Mountains. In this study, we have sequenced the complete chloroplast genome of , which is 152,643 bp in length, including two inverted repeat (IR, 25,829 bp) regions, one large single copy region (LSC) and one small single copy region (SSC) of 83,191 bp and 17,794 bp, respectively. The cp genome has 131 annotated genes, including 86 protein-coding genes, 37 tRNA genes, and eight rRNA genes.

MiR-34c-5p plays a protective role in chronic obstructive pulmonary disease via targeting .

To study the role of miR-34c-5p targeting in affecting the progression of chronic obstructive pulmonary disease (COPD). The dual-luciferase reporter gene assay was applied to verify the targeting relationship of miR-34c-5p and . The rats were randomly assigned into Control, COPD, COPD + empty plasmids, COPD + agomir, COPD + CCL22 shRNA and COPD + agomir + CCL22 groups.

Development, characterization, and cross-amplification of microsatellite markers for (Caryophyllaceae).

Premise Of The Study: (Caryophyllaceae) is a narrowly distributed and endemic plant species in southwestern China. The overexploitation of natural has led to the destruction of many populations. Population and genetic studies will provide crucial data for the protection and management of .

Tetrandrine triggers an alternative autophagy in DU145 cells.

Tetrandrine (Tet), a potent lysosomal inhibitor, blocks autophagic flux and induces cancer cell death. Previously, the present authors identified the prostate cancer cell line DU145 to exhibit high sensitivity towards Tet in 11 cancer cell lines. In the present study, autophagy in Tet-treated DU145 cells was investigated.

Zinc-Mediated C-3 α-Prenylation of Isatins with Prenyl Bromide: Access to 3-Prenyl-3-hydroxy-2-oxindoles and Its Application.

A convenient and highly α-regioselective strategy for the synthesis of 3-prenyl-3-hydroxy-2-oxindoles has been developed starting from isatins and prenylzinc with good to excellent yields. This protocol provides a straightforward and practical way to introduce an α-prenyl moiety into the C-3 position of isatins. The advantages of this reaction are use of the cheap and readily available reagents, operational simplicity, and wide substrate scope.

Synthesis of Furo[3,2-c]benzopyrans via an Intramolecular [4 + 2] Cycloaddition Reaction of o-Quinonemethides.

An intramolecular [4 + 2] cycloaddition reaction of o-quinonemethides generated from salicylaldehydes and α-prenylated alcohols is described. In the presence of a catalytic amount of benzenesulfonic acid (BSA), the reaction proceeded smoothly in EtOH to afford furo[3,2-c]benzopyrans through a three-bond forming process in moderate to excellent yields with high diastereoselectivity. This reaction provides a simple and straightforward protocol to efficiently construct furo[3,2-c]benzopyran skeletons.

The relationship between laminoplasty opening angle and increased sagittal canal diameter and the prediction of spinal canal expansion following double-door cervical laminoplasty.

Purpose: To clarify the relationship between laminoplasty opening angle (LOA) and the increase in sagittal canal diameter (SCD) in double-door cervical laminoplasty (DDCL) and to predict the increase in SCD using the resulting formula.

Methods: We analyzed 20 patients with multilevel cervical spondylotic myelopathy who underwent DDCL between September 2010 and January 2013. The pre- and post-operative parameters of the cervical spinal canal were measured by computed tomography.

[Isolation and diversity analyses of endophytic fungi from Paris polyphylla var. yunnanensis].

The paper is aimed at studying the diversity of endophytic fungi community from Paris polyphylla var. yunnanensis, and to provide a scientific basis for the utilization value of the endophytic fungi as bioactive material resources. In the present study, endophytic fungi were isolated from roots, rhizomes and leaves of wild P.

[Relationship between skin carotenoid level and metabolic syndrome related indices].

Objective: To provide scientific rationales through an analysis of the relationship between skin carotenoid level and metabolic syndrome related indices so as to prevent the occurrences of metabolic syndrome (MS).

Methods: A total of 493 cases from December 2010 to December 2011 were recruited to measure the skin carotenoid levels and various laboratory indices of metabolic syndrome.

Results: Along with the rising risk factors of MS, the skin carotenoid level declined.

[Study on treatment of methylene blue wastewater by fly ash adsorption-Fenton and thermal regeneration].

The physicochemical properties of water-washed fly ash (FA) and acid modified fly ash (M-FA) were investigated. The adsorption of methylene blue by FA and M-FA were studied by batch experiments. Two methods, Fenton-drive oxidation regeneration and thermal regeneration, were used for regeneration of the used FA and M-FA.

[Characterization and thermodynamic properties of Cu(II) imprinted chitosan crosslinked membrane].

A new type of Cu(II)-imprinted chitosan crosslinked membrane (IM Cu(II)-E-CTS) was prepared via molecular imprinting technology, chemical pre-crosslinking and crosslinking methods for treatment of wastewater containing low concentration of copper ion. IM Cu(II)-E-CTS was characterized by porosity, swelling ratio, amino group content, surface morphology, functional group and crystallinity. The thermodynamic properties of Cu (II) adsorption on the as-synthesized membrane at the low concentration (20-70 mg x L(-1)) were studied.

[Construction of shRNA eukaryotic expression vectors of pkm2 gene and their effect on drug resistant cell line of acute promyelocytic leukemia].

This study was aimed to construct the shRNA eukaryotic expression vectors of M2-pyruvate kinase gene (pkm2) and to investigate the effects of pkm2 gene interference on the drug resistance of acute promyelocytic leukemia (APL) cells in vitro. Three specific shRNAs of pkm2 gene were designed and cloned into PBSU6 vector containing a U6 promotor. The constructed plasmids were identified and proved by the restriction sequence analysis.

[Utilizing fly ash to prepare polysilicon acid and compounded PFS and the study of its properties].

Fly ash which is a kind of solid waste of power station in Dalian was prepared as polysilicon acid, and compound polymerized ferric sulphate and its properties was studied. Fly ash was dipped in NaOH solution. The effects of temperature, concentration of NaOH solution and reactive time were examined respectively on the conversion efficiencies of silicon.

[Fly ash-catalyzed oxidation of p-nitro phenol with H2O2].

Fly ash was investigated as a catalyst in the oxidation of p-nitro phenol (PNP) with H2O2 at ambient temperature and pressure. The physical and chemical properties of fly ash were analyzed. The effects of fly ash composition, pretreatment methods and other parameters (such as dosage, pH, reaction time and oxidant concentration) on PNP removal rate were studied.

[Characteristics of adsorption and desorption isotherm of cresol isomers on activated carbon].

Simulated wastewater containing o-, m- and p-cresol was used respectively to study the effects of substituted position on adsorption and desorption and the feasibility of activated carbon adsorption-bioregeneration treatment. According to the isotherm, the adsorbability sequences in the order of p-cresol > o-cresol > m-cresol, which is positively correlated to pK(a) and negatively correlated to solubility and critical oxidation potential (COP); and the desorbability sequences in the order of o-cresol > m-cresol > p-cresol, which is negatively correlated to boiling point and viscosity. According to comparative analysis, irreversible adsorption is found to be the main reason for differences between adsorption and desorption isotherms.

Women's cancers in developing countries: from research to an integrated health systems approach.

The article focuses on two women's cancers, breast and cervical cancer, that are much more deadly in developing countries than in developed countries. Early detection can make a significant difference for the treatment outcome of these two cancers and there are now cost-effective tools for prevention and screening. The authors propose a new public health approach to these two cancers in developing countries where resources for effective cancer control are very limited and offer a framework for putting women's cancers in developing countries on the global public health agenda.

[Adsorption property of chitosan composite resin for nitrite-nitrogen].

A novel composite resin of chitosan supported by activated carbon was prepared using the emulsification cross-linking technique. The adsorption properties of the resin for NO2(-)-N were studied. It is found that there are many developed micropores on the surface of the resin.