Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling.

: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer (BC). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC.

[Analysis on water-soluble inorganic ions in the atmospheric aerosol of Xinglong].

Size-segregated aerosol samples were collected using Andersen cascade sampler from Sep. 2009 to Aug. 2010 in Xinglong, a regional atmospheric background station.

[Progress of diagnosis and treatment of precancerous pathological lesions of mammary cancer].

Prevention and treatment of mammary cancer has been taken into great account recently. "Mutistage developing mode" provides the basis for interrupting and reversing precancerous changes. Traditional Chinese medicine (TCM) has shown effects on precancerous changes through inhibiting angiogenesis, promoting apoptosis, modulating endocrine system and restraining oncogene expression.

[Clinical research on relationship between angiogensis and TCM syndrome type of cyclomastopathy].

Objective: To study the relationship between angiogensis and TCM Syndrome type of cyclomastopathy (CMP) to investigate the objective standardization of TCM Syndrome diagnosis of the disease.

Methods: One hundred and forty patients with CMP were divided into three groups according to TCM syndrome typing. The pathological type, grade and expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvascular density (MVD) in mammary biopsy were observed.

[Rosiglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice].

Objective: To study the effect of rosiglitazone on atherosclerosis and potential mechanism in ApoE-knockout mice.

Methods: Thirty-two 6-week-old ApoE-knockout mice were used as atherosclerosis model in two groups: rosiglitazone group (n = 18) and control group (n = 14). Each group contained equal numbers of male and female mice.

[Biocompatibility of polyester net in the cornea of rabbits].

Objective: To explore biocompatibility and biohealing characteristics of a polyester net with cornea after the net implanted into the cornea lamina.

Methods: Twenty New Zealand rabbits weighing 2.0 - 2.

Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma.

Aim: To investigate the expression and significance of heat shock protein 70 (HSP70) and glucose-regulated protein 94 (grp94) in human esophageal carcinoma and adjacent normal tissues.

Methods: The expression of HSP70 and grp94 in 78 human esophageal cancer and adjacent normal tissues was studied by immunohistochemistry and pathology photograph analysis.

Results: Both esophageal cancer and adjacent normal tissues could express HSP70 and grp94.

Antitumor immunity induced by DNA vaccine encoding alpha-fetoprotein/heat shock protein 70.

Aim: To construct a DNA vaccine encoding human alpha-fetoprotein (hAFP)/heat shock protein 70 (HSP70), and to study its ability to induce specific CTL response and its protective effect against AFP-expressing tumor.

Methods: A DNA vaccine was constructed by combining hAFP gene with HSP70 gene. SP2/0 cells were stably transfected with pBBS212-hAFP and pBBS212-hAFP/HSP70 eukaryotic expression vectors.