Publications by authors named "Ai-jun Shen"
Article Synopsis
- This study aimed to assess the effectiveness of amide proton transfer (APT) imaging in evaluating key molecular markers (Ki-67, p53, and PD-L1) in bladder cancer compared to diffusion-weighted imaging (DWI).
- The research involved 88 bladder cancer patients, revealing significant correlations between APT imaging results and levels of the molecular markers, indicating that higher APT values are linked to more aggressive cancer features.
- The findings suggest that APT imaging may provide valuable insights for preoperative assessments and treatment decisions, potentially outperforming DWI in accuracy.
Article Synopsis
- The study focuses on using a novel functional MRI technique called amide proton transfer (APT) to assess renal fibrosis (RF) noninvasively, a crucial factor in chronic kidney disease (CKD) progression.
- Male Sprague-Dawley rats were subjected to different kidney injury models, and their APT values were measured and compared with histology results, while also including human patients who underwent similar imaging before renal biopsy.
- Findings revealed that APT values correlated positively with the extent of RF in both rats and humans, suggesting that APT offers a superior diagnostic capability over traditional methods in detecting early-stage fibrosis, especially when combined with other imaging metrics.
Background: Conventional magnetic resonance imaging (MRI) has certain limitations in distinguishing between malignant and benign urinary bladder (UB) lesions. Amide proton transfer (APT) imaging may provide more diagnostic information than diffusion-weighted imaging (DWI) to distinguish between malignant and benign UB.
Purpose: To investigate the potential of APT imaging in the diagnosis of malignant and benign UB lesions and to compare its diagnostic efficacy with that of conventional DWI.
Purpose: To assess the ability of amide proton transfer (APT) imaging, in comparison with diffusion-weighted imaging (DWI), to differentiate low-grade from high-grade bladder tumors and predict the aggressiveness of bladder cancer (BCa).
Methods: Forty-eight patients diagnosed with BCa confirmed by histopathological findings who underwent magnetic resonance (MR) imaging, including APT imaging and DWI (b = 0, 1000 sec/mm), were enrolled in this study. The asymmetric magnetization transfer ratio (MTR) was defined as the magnetization transfer asymmetry at 3.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFTo assess the efficacy of the combination of sonographic morphology score (SMS) with CA125 and HE4 for detecting recurrent pelvic ovarian carcinoma (OC). Data of 58 OC patients treated in our hospital between 2014 and 2016 were analyzed. After cytoreductive surgery and routine chemotherapy, all patients were followed up by transvaginal ultrasound examination (SMS for pelvic masses based on volume and structure scores) and tumor marker (serum CA125 and HE4) detection.
View Article and Find Full Text PDFHistone deacetylases (HDACs), especially HDAC1, 2, 3 and 4, are abundantly expressed and over-activated in prostate cancer that is correlated with the poor prognosis. Thus, inhibition of HDAC activity has emerged as a potential alternative option for prostate cancer therapy. Chromopeptide A is a depsipeptide isolated from the marine sediment-derived bacterium Chromobacterium sp.
View Article and Find Full Text PDFAim: Inhibition of heat shock protein (Hsp90) has been proven to be effective in overriding primary and acquired resistance of kinase inhibitors. In this study, we investigated the role of FS-108, a newly developed Hsp90 inhibitor, to overcome gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Methods: Cell proliferation was assessed using the SRB assay.
Polyelectrolyte layer-by-layer assembled lipid nanoparticles (NPs) were prepared to improve their stability against lipolysis in gastrointestinal tract, and efficiency of oral absorption of doxorubicin (DOX). The lipid NPs were prepared by hot melt-probe sonication method. The polyelectrolyte layer-by-layer assembled lipid NPs (DOX-NPs/CS/γ-PGA) was prepared by layer-by-layer self-assembling polyelectrolytes cationic chitosan (CS) and anionic poly (γ-glutamic acid) (γ-PGA) on the surface of lipid NPs based on electrostatic interaction.
View Article and Find Full Text PDFBecause of its unique chemical and physical properties, graphene oxide (GO) has attracted a large number of researchers to explore its biomedical applications in the past few years. Here, we synthesized a novel multifunctional nanocomposite based on GO and systemically investigated its applications for in vitro hepatocarcinoma diagnosis and treatment. This multifunctional nanocomposite named GO-PEG-FA/Gd/DOX was obtained as the following procedures: gadolinium-diethylenetriamine-pentaacetic acid-poly(diallyl dimethylammonium) chloride (Gd-DTPA-PDDA) as magnetic resonance imaging (MRI) probe was applied to modify GO by simple physical sorption with a loading efficiency of Gd(3+) up to 0.
View Article and Find Full Text PDFAim: We aimed to investigate the potential modification of previously unrecognized surface glycoprotein(s) by alpha2,6-sialylation other than by integrins.
Methods: The expression of beta-galactoside alpha2,6-sialyltransferase (ST6Gal-I) in the colon cancer cell line HCT116 was reduced by siRNA. The adhesion and Boyden chamber assay were used to detect the variation in cell motility.