Publications by authors named "Ai-hong Zhu"
Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis.
Medicine (Baltimore)
February 2016
Article Synopsis
- Cryptococcal meningitis (CM) is a serious global disease affecting both HIV-infected and previously healthy patients, yet the immune responses in previously healthy patients (PHPs) are not well understood.
- A study analyzing 41 CM patients found that PHPs had higher counts of certain immune cells compared to non-PHPs, but similar levels of inflammatory markers, aside from lower immunoglobulin A (IgA) in non-PHPs.
- Despite PHPs having a higher five-year mortality rate than non-PHPs (22% vs. 12.5%), this difference was not statistically significant; however, higher immunoglobulin G (IgG) levels in serum during the disease onset may indicate increased mortality
Objective: To establish an animal model of chronic optic nerve injury which is suitable for experimental research.
Methods: Dil, a tracer, was injected through the bone windows into the brain of 48 cats so as to mark the retinal ganglion cells (RGCs). Two weeks later the 48 cats were randomly divided into 6 equal groups.