Publications by authors named "Ai-guo You"
Article Synopsis
- Severe Fever with Thrombocytopenia Syndrome (SFTS) is a serious disease caused by the SFTS virus, which is spreading in East Asia and has a high mortality rate.
- A study in Henan Province, China, tested 615 animals (both domestic and wild), revealing that 44.72% had antibodies against the virus, with no significant differences between the two groups.
- The research also found that 17.07% of the animals were positive for the virus itself, with a strain isolated from a yellow weasel, indicating that these animals may serve as natural reservoirs for SFTSV.
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that is caused by a novel bunyavirus, referred to as SFTS virus. During January 2011 to December 2011 we conducted a case-control study in Henan, Hubei and Shandong Provinces of China to determine the risk factors for SFTS.
Methods: Case-patients were identified in hospitals and reported to provincial Centers for Disease Control and Prevention while being notified electronically to the National Surveillance System.
Background: Fast resting heart rate might increase the risk of developing type 2 diabetes mellitus (T2DM). However, it is unclear whether resting heart rate could be used to predict the risk of undiagnosed T2DM. Therefore, the purposes of this study were to examine the association between resting heart rate and undiagnosed T2DM, and evaluate the feasibility of using resting heart rate as a marker for identifying the risk of undiagnosed T2DM.
View Article and Find Full Text PDF[Expression and significance of DNA methyltransferase in sera of patients with lung cancer].
Zhonghua Yi Xue Za Zhi
December 2013
Objective: To explore the protein expressions of DNMT1, DNMT3a and DNMT3b in sera of lung cancer patients.
Methods: Enzyme-linked immunosorbent assay (ELISA) method was used to measure the protein expressions of DNMT1, DNMT3a and DNMT3b in 136 lung cancer patients hospitalized at Department of Respiratory Diseases, First Affiliated Hospital, Zhengzhou University during September 2012 to June 2013. And 147 healthy controls were selected from a population of physical examination at Sixth People's Hospital of Zhengzhou.
Article Synopsis
- Severe fever with thrombocytopenia syndrome (SFTS) is a deadly disease in China caused by New Bunyavirus, with a case fatality rate of around 12%, and currently has no vaccine or antiviral treatments available.
- Researchers developed a new, rapid testing method called reverse transcription-loop-mediated isothermal amplification (RT-LAMP) to detect New Bunyavirus efficiently, with high accuracy and no false positives from similar viruses.
- The RT-LAMP method showed 99% sensitivity and 100% specificity when compared to traditional real-time RT-PCR tests, making it a promising option for diagnosing SFTS, especially in hospitals with limited resources.
[Etiology surveillance of hand-foot-mouth disease in Henan province between 2008 and 2011].
Zhonghua Yu Fang Yi Xue Za Zhi
October 2012
Objective: To understand etiological types and distribution features of hand-foot-mouth disease (HFMD) in Henan province between 2008 and 2011.
Methods: A total of 30 486 specimens of feces, rectal swabs or throat swabs from HFMD patients were collected by each Municipal CDC in Henan from 2008 to 2011. The enterovirus 71 (EV71), coxsackie virus A16 (CA16) and other enterovirus (EV) were detected by RT-PCR or real time RT-PCR.
Background: Resting pulse rate has been observed to be associated with cardiovascular diseases. However, its association with lipid metabolic dysfunctions remains unclear, especially resting pulse rate as an indicator for identifying the risk of lipid metabolic dysfunctions. The purpose of this study was to examine the association between resting pulse rate and lipid metabolic dysfunctions, and then evaluate the feasibility of resting pulse rate as an indicator for screening the risk of lipid metabolic dysfunctions.
View Article and Find Full Text PDF[Analysis on the diagnosis and treatment of a cluster of cases infected by new bunyavirus].
Zhonghua Yu Fang Yi Xue Za Zhi
February 2012
Objective: To analyze and summarize the clinical characteristics, experience of diagnosis and treatment of cases infected by new bunyavirus, which occurred in Henan province in 2010.
Methods: The clinical characteristics and effect of diagnosis and treatment of 5 cases were analyzed using descriptive epidemiological method. Blood specimens were detected by RT-PCR and pathogen separation.
[Analysis of the epidemic characteristics of fever and thrombocytopenia syndrome in Henan province, 2007 - 2011].
Zhonghua Yu Fang Yi Xue Za Zhi
February 2012
Objective: To analyze the epidemiological characteristics of fever thrombocytopenia and leukopenia syndrome (FTLS) in Henan province, China in 2007 - 2011.
Methods: Data from specific surveillance system for FTLS in Henan and Information Management System of Chinese Center for Disease Control and Prevention were used to collect the information of the cases.Descriptive epidemiological methods were used to analyze the surveillance data during 2007 - 2011.
[Analysis on clinical and epidemiological characteristics of severe cases infected by EV71].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
December 2010
Objective: To explore the clinical and epidemiological characteristics of serious cases of hand-foot-and-mouth disease (HFMD) infected by EV71, in order to provide scientific evidence for prevention and control of HFMD.
Methods: Information was collected by questionaires through consulting medical cases. Data was input by Epidata, and analysed by software SAS 9.