Publications by authors named "Ai-Zhong Shao"
Article Synopsis
- - Immune checkpoint inhibitors (ICIs) have revolutionized tumor treatment by offering high specificity and low side effects, particularly targeting the PD-1/PD-L1 axis which plays a crucial role in how tumors evade the immune system
- - Understanding the regulatory factors affecting the PD-1/PD-L1 axis is essential for enhancing the effectiveness of ICIs and improving patient outcomes in cancer therapy
- - Non-coding RNAs (ncRNAs) have been shown to influence PD-L1 expression in the tumor immune microenvironment, thereby affecting the success of ICI therapies and highlighting their potential as targets for more effective cancer treatments
Background: The most common subtype of lung cancer, called lung adenocarcinoma (LUAD), is also the largest cause of cancer death in the world. The aim of this study was to determine the importance of the METTL7A gene in the prognosis of patients with LUAD.
Methods: This particular study used a total of four different LUAD datasets, namely TCGA-LUAD, GSE32863, GSE31210 and GSE13213.
Esophageal squamous cell carcinoma (ESCC) is one of the subtypes of esophageal cancer with Chinese characteristics, and its five-year survival rate is less than 20%. Early diagnosis is beneficial to improving the survival rate of ESCC significantly. Quantitative Real-Time Polymerase Chain Reaction is a high-throughput technique that can quantify tumor-related genes for early diagnosis.
View Article and Find Full Text PDFBackground: As a key regulator of metabolic pathways, long non-coding RNA (lncRNA) has received much attention for its relationship with reprogrammed fatty acid metabolism (FAM). This study aimed to investigate the role of the FAM-related lncRNAs in the prognostic management of patients with lung adenocarcinoma (LUAD) using bioinformatics analysis techniques.
Methods: We obtained LUAD-related transcriptomic data and clinical information from The Cancer Genome Atlas (TCGA) database.
Background: Gastric cardia adenocarcinoma (GCA) is a common malignant tumor of the digestive tract with a high incidence in China. Genetic factors such as single nucleotide polymorphisms (SNPs) may contribute to the carcinogenesis of GCA.
Methods: We conducted a hospital-based case-control study to evaluate the genetic association of functional SNPs with susceptibility to GCA development.
Background: The relationship between elastolytic matrix metalloproteinases (MMPs) (such as MMP-2, MMP-9) and thoracic aortic dissection (TAD) has been described, but little is known regarding the role of collagenolytic MMPs in thoracic aortic dissection. The aim of this study was to determine the role of MMP-8 in acute thoracic aortic dissection.
Materials And Methods: Forty-five patients affected by TAD and 40 with acute myocardial infarction (AMI) were recruited into this study.