Publications by authors named "Ai-Zhi Lin"
Breast cancer (BC) is a common malignant tumor in women and requires a comprehensive understanding of its pathogenesis for the development of new therapeutic strategies. Polyunsaturated fatty acids (PUFAs) metabolism-driven inflammation is a causative factor in cancer development. However, the function of PUFAs' metabolism in BC remains largely unknown.
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- A high-sucrose diet (HSD) leads to gut barrier dysfunction, including colon inflammation and tight junction damage, as observed in a mouse model over 16 weeks.
- Metabolomic analysis revealed increased soluble epoxide hydrolase (sEH) levels and decreased 5(6)-epoxyeicosatrienoic acid (5(6)-EET) in the colon, suggesting sEH as a therapeutic target for HSD-related injuries.
- Treatment with an sEH inhibitor or genetic knockout of the sEH gene reduced intestinal injuries, while 5(6)-EET showed anti-inflammatory effects and improved tight junctions, unlike its product 5,6-dihydroxyeicosatrienoic acid (5
Aims: Deoxynivalenol (DON), namely vomitoxin, is one of the most prevalent fungal toxins in cereal crops worldwide. However, the underlying toxic mechanisms of DON remain largely unknown.
Main Methods: DON exposure-caused changes in the murine plasma metabolome and gut microbiome were investigated by an LC-MS/MS-based nontargeted metabolomics approach and sequencing of 16S rRNA in fecal samples, respectively.