Publications by authors named "Ai-Ning Wu"
Background: Recurrent spontaneous abortion (RSA) is characterized by the occurrence of two or more consecutive spontaneous abortions, with a rising prevalence among pregnant women and significant implications for their physical and mental well-being. The multifaceted etiology of RSA has posed challenges in unraveling the molecular mechanisms underlying that underlie its pathogenesis. Oxidative stress and immune response have been identified as pivotal factors in the development of its condition.
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- The study evaluated the effectiveness of karyotyping via amniocentesis compared to next generation sequencing (NGS)-based noninvasive prenatal DNA testing (NIPT) for detecting fetal chromosomal disorders.
- A total of 2,267 high-risk pregnant women underwent NIPT, with 29 positive results leading to follow-up amniocentesis, which confirmed diagnoses in 20 cases.
- Results showed that NIPT demonstrated high sensitivity and specificity for identifying conditions like trisomy 21, 13, and 18, suggesting that using NGS alongside traditional methods enhances the accuracy of prenatal diagnosis.