Measles Outbreak in Pediatric Hematology and Oncology Patients in Shanghai, 2015.

Background: Despite substantial progress toward measles control are making in China, measles outbreaks in immunocompromised population still pose a challenge to interrupt endemic transmission. This study aimed to investigate the features of measles in pediatric hematology and oncology patients and explore the reasons behind the outbreak.

Methods: We collected demographic, epidemiological, and clinical data of immunocompromised measles children.

[Profiles of innate immune receptors and cytokines in peripheral blood mononuclear cells in children with measles].

Objective: The aim of this study was to explore the roles and clinical significance of innate immune receptors and cytokine in children with measles.

Method: The children with measles hospitalized in the department of infectious diseases, Children's Hospital of Fudan University during 2009-2011 were enrolled into measles group, while the healthy children examined in well baby clinic were enrolled into control group. The mRNA expression of TLR2/3/4/7, melanoma differentiation-associated gene-5 (MDA-5), retinoic acid-inducible gene I (RIG-I), IFN-α/β and IL-10 in peripheral blood mononuclear cells were detected by real-time PCR.

[The first confirmed pediatric case with H7N9 avian influenza virus infection in China].

Objective: To understand the clinical and epidemiological aspects of avian influenza A (H7N9) virus infection in children.

Method: The clinical data of the first confirmed pediatric case of avian influenza A(H7N9) virus infection were collected, and the epidemiological information, presenting symptoms, laboratory investigation, management and outcome were analyzed. The data of the pediatric cases were also compared with those of the adults cases.