Publications by authors named "Ai-Lun Tseng"
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that leads to chronic inflammation of joints and tissues, and gut microbiota changes may play a key role in immune dysfunction associated with RA.
- Treatments for RA may influence gut microbiota diversity, suggesting that maintaining or modifying gut bacteria could be an important strategy for managing the disease.
- In a study, B. coagulans BACO-17 showed promise as a new treatment by reducing symptoms of RA and protecting joint tissues, indicating its potential for further research as a therapeutic option.
Article Synopsis
- Obesity is a major global health issue linked to inflammation in fat tissues and gut microbiota disruptions, prompting research into probiotics as potential treatments.
- The study tested two probiotics, SG069 (LR069) and SG031 (LB031), on mice with high-fat diets for 12 weeks, revealing that LB031 improved lipid metabolism and reduced inflammation, while LR069 led to weight loss and enhanced fat breakdown.
- The findings illustrate distinct mechanisms by which LR069 and LB031 affect obesity and lipid metabolism, suggesting their potential for targeted obesity interventions and highlighting the connection between gut health and metabolic disorders.
Drug repurposing has become an increasingly attractive approach to drug development owing to the ever-growing cost of new drug discovery and frequent withdrawal of successful drugs caused by side effect issues. Here, we devised Functional Module Connectivity Map (FMCM) for the discovery of repurposed drug compounds for systems treatment of complex diseases, and applied it to colorectal adenocarcinoma. FMCM used multiple functional gene modules to query the Connectivity Map (CMap).
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