Publications by authors named "Ai-Hui Ye"
A tandem dearomative electrophilic thiocyanation/cyclization/acylation of indoles was developed for the first time, which is enabled by acyl chloride. A variety of 3-SCN pyrroloindolines were obtained with moderate to excellent yields. Interestingly, following replacement of acyl chloride with methanesulfonic acid, 2-SCN tryptamines were obtained using the same starting substrates and reagents.
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- The study introduced a new method for electrophilic thiocyanation of 3-aryl indoles using phosphoric acid as a catalyst, enabling the production of SCN-containing compounds efficiently.
- A diverse range of 2-SCN-3-aryl indoles were synthesized with yields ranging from moderate to excellent.
- Additionally, the research explored the use of chiral phosphoric acid, resulting in axially chiral SCN-containing compounds with moderate enantioselectivity.
An electrophilic thiocyano semipinacol rearrangement of allylic alcohols has been achieved for the first time by using -thiocyano-dibenzenesulfonimide (NTSI). This approach provides a direct, simple, and efficient strategy for the formation of thiocyano carbonyl compounds with moderate to excellent yields. Meanwhile, an all-carbon quaternary center was rapidly constructed.
View Article and Find Full Text PDFNumerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. This approach provides efficient, simple, and modular methods for the formation of SCN-containing heterocycles such as lactones, tetrahydrofurans, dihydrofurans, and dihydrobenzofurans in moderate to excellent yields. Meanwhile, diverse oxa-quaternary centers were rapidly constructed.
View Article and Find Full Text PDF[p53 gene intron 7 polymorphism and its association with oral neoplasms].
Zhonghua Kou Qiang Yi Xue Za Zhi
September 2005
Objective: To investigate the association between oral neoplasm genetic susceptibility and genetic polymorphism of p53 intron 7.
Methods: The intron 7 ApaI polymorphism of p53 was analyzed in 95 oral neoplasm patients and 105 healthy individuals by utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping assay technique, and direct sequencing was performed in 30 cases which were selected from the patients and controls by random sampling.
Results: In oral neoplasms cases, haplotype combinations were T-G 43.