Effects of nebulized high-dose budesonide on moderate-to-severe acute exacerbation of asthma in children: a randomized, double-blind, placebo-controlled study.

Background And Objective: The efficacy of inhaled corticosteroids (ICS) in asthma exacerbation are yet to be clarified. The aim of this study was to investigate the efficacy of nebulized ICS in children with moderate-to-severe acute exacerbation of asthma in an emergency room setting in order to elucidate the potential use of ICS as the first-line therapy in the management of acute exacerbation of asthma.

Methods: This was a prospective, randomized, double-blind, placebo-controlled study.

Respiratory syncytial virus induces leukotriene C4 synthase expression in bronchial epithelial cells.

Background And Objective: Respiratory syncytial virus (RSV) results in acute wheezing in infants and is frequently associated with recurrent wheezing. Although RSV-induced wheezing clinically resembles that of asthma, corticosteroids are not equivalently effective in RSV-associated wheezing. The study sought to determine the mechanisms of RSV-induced wheezing by establishing an in vitro model of RSV-infected human bronchial epithelial cells (16-HBEC).

[The efficacy of nebulized budesonide in acute moderate to severe exacerbations of asthma in children].

Objective: To evaluate the effect of nebulized budesonide (BUD) in acute moderate to severe exacerbations of asthma in children.

Methods: Forty children, 5 to 15 years of age, with acute moderate to severe attacks of asthma, were randomized into BUD group and control group, receiving nebulized 0.5% salbutamol (150 µg/kg) + 0.

[Questionnaire-based survey of allergic diseases among children aged 0 - 14 years in the downtown of Beijing, Chongqing and Guangzhou].

Objective: In recent years, the incidence of allergic diseases in China is increasing. With serious influence on the patients' quality of life and even life-threatening, now allergic diseases have become an important public health problem in our country. This survey aimed to obtain a general epidemic outline of children's major allergic diseases, i.

Current trends of the prevalence of childhood asthma in three Chinese cities: a multicenter epidemiological survey.

Objective: To analyze the prevalence of asthma and asthma related symptoms among children aged 0-14 years in three Chinese cities and to obtain a crude estimation of the trend of childhood asthma prevalence in China.

Methods: A cross-sectional, population-based survey of prevalence of asthma was conducted in children aged from 0 to 14 years in 3 major cities of China (Beijing, Chongqing, and Guangzhou) with different geographic locations. All the subjects were randomly selected by a multi-stage sampling method.

[Simultaneous treatment of asthma and allergic rhinitis in children with a nasally inhaled glucocorticosteroid].

Objective: To assess the efficacy of a nasally inhaled corticosteroid (ICS) through a spacer with mask aiming at simultaneous treatment of allergic rhinitis and asthma in children and make an analysis on the costs.

Method: A total of 72 children with allergic rhinitis (AR) and asthma were randomized into two groups. Experimental group received budesonide inhaler (400 microg/d) through the nose using a spacer attached to a face mask, control group children orally inhaled budesonide dry powder (400 microg/d) plus a nasal spray of budesonide aquae (256 microg/d).

[Relationship between the efficacy of inhaled corticosteroids and the leukotriene expression in children with asthma].

Objective: To evaluate the relationship between leukotriene expression in blood polymorphonuclear leukocytes (PMNL) and the efficacy of inhaled corticosteroids (ICS) in children with asthma.

Methods: Thirty-two children with asthma (5-12 years) and ten healthy children (control group) were enrolled. The asthmatic children were subdivided into ICS well-controlled and ICS poorly-controlled groups based on their clinical symptoms and lung function.

[Therapeutic efficacy and follow-up study of inhaled corticosteroids vs. oral montelukast in treatment of cough variant asthma].

Objective: To compare the effects of inhaled corticosteroids (ICS) and oral leukotriene modifier (LTM) montelukast on the prognosis of children with cough variant asthma (CVA), and to identify the related risk factors for the development of classic asthma in children with CVA.

Methods: Eighty-four children with CVA (2 - 6 yrs) were randomized to receive inhaled beclomethasone dipropionate 200 microg/d through pressurized metered-dose inhaler (MDI) plus spacer with mask or oral montelukast 5 mg, once at bedtime for 6 months, then followed by 18 months observation period after the end of the study medication.

Results: There was no significant difference in antitussive days between the two groups (ICS group: 14 +/- 9 days, LTM group: 13 +/- 9 days, Z = 1.

[A new method to detect expiratory flow limitation in chronic obstructive pulmonary disease patients].

Objective: To explore the significance of negative expiratory pressure (NEP) technique in detecting expiratory flow limitation (EFL) in the chronic obstructive pulmonary disease (COPD) patients.

Methods: NEP technique was performed on 54 COPD patients, 45 males and 9 females, aged 69+/-10 (Group A), 8 COPD patients who failed to receive the routine pulmonary function tests (Group B), and 10 normal controls. The subjects in 3 groups, matched in age, height, body weight, and educational level, underwent 5-point EFL scoring, Medical Research Council (MRC) dyspnea scoring, 6-min walk distance scoring, and routine pulmonary ventilation function test.

[Expiratory flow limitation detected by negative expiratory pressure in patients with bronchial asthma].

Objective: To evaluate the relationship between expiratory flow limitation (EFL) and chronic dyspnea and the effect of bronchodilator on EFL in patients with bronchial asthma.

Methods: Sixty-five patients with bronchial asthma were treated for pre- and post-bronchodilation of 400 microg salbutamol.

Results: EFL was detected in 26 (40%) of the 65 bronchial asthma patients, 11 only in supine position and 15 in both sitting and supine positions.

[Expiratory flow limitation detected by negative expiratory pressure in patients with chronic obstructive pulmonary disease].

Objective: To evaluate the relationship between expiratory flow limitation (EFL) and chronic dyspnea and the effect of bronchodilator on EFL in patients with chronic obstructive pulmonary disease (COPD).

Methods: Thirty-three ambulatory patients with COPD (46 - 78 yrs; male 31, female 2) were included in this study. The severity of chronic dyspnea was rated according to the dyspnea scale proposed by the Medical Research Council (MRC).