Publications by authors named "Ai-Fan Ji"
[Apoptosis-inducing effects of brucine on human chronic myeloid leukemia cell line K562].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2011
Article Synopsis
- Brucine effectively inhibits the growth of K562 human chronic myeloid leukemia cells in a concentration- and time-dependent manner, with the highest inhibition rate of 94.0% observed at 400 µg/ml after 72 hours.
- The induction of apoptosis in K562 cells by brucine was confirmed through various staining methods, revealing nuclear chromatin condensation and typical apoptotic morphology at higher concentrations.
- DNA gel electrophoresis showed characteristic laddering in K562 cells treated with 400 µg/ml of brucine for 72 hours, indicating that brucine promotes apoptosis in a dose-dependent manner within the range of 50 to 400 µg/ml.