Discovery of new pesticide candidates from nature: design, synthesis and bioactivity research of rutaecarpine derivatives.

Background: The invasion of viruses and fungi can cause pathological changes in the normal growth of plants and is an important factor in causing plant infectious diseases. These pathogenic microorganisms can also secrete toxic metabolites, affecting crop quality and posing a threat to human health. In this work, we selected the natural product rutaecarpine as the lead compound to achieve the total synthesis and structural derivation.

Pityriacitrin marine alkaloids as novel antiviral and anti-phytopathogenic-fungus agents.

Background: Plant diseases have been gripping agricultural production, seriously affecting the growth and yields of crops. Marine natural products are an important source for novel drugs discovery. In this work, pityriacitrin marine alkaloids were selected as the parent structures.