Cilia-Inspired Bionic Tactile E-Skin: Structure, Fabrication and Applications.

The rapid advancement of tactile electronic skin (E-skin) has highlighted the effectiveness of incorporating bionic, force-sensitive microstructures in order to enhance sensing performance. Among these, cilia-like microstructures with high aspect ratios, whose inspiration is mammalian hair and the lateral line system of fish, have attracted significant attention for their unique ability to enable E-skin to detect weak signals, even in extreme conditions. Herein, this review critically examines recent progress in the development of cilia-inspired bionic tactile E-skin, with a focus on columnar, conical and filiform microstructures, as well as their fabrication strategies, including template-based and template-free methods.

Remimazolam for the prevention of emergence agitation in adults following nasal surgery under general anesthesia: a prospective randomized clinical controlled trial.

Background: Remimazolam is a novel intravenous sedative/anesthetic drug that belongs to the ultra-short-acting class of benzodiazepines. The purpose of this study was to evaluate the effectiveness of postoperative use of remimazolam in preventing emergence agitation (EA) in adults following nasal surgery.

Methods: Patients who underwent nasal surgery were randomly divided into Group R and Group C.

Impact of surgical volume on outcomes of laparoscopic adrenalectomy for benign adrenal tumors: A Japanese nationwide database analysis.

Objective: To analyze the recent status of laparoscopic adrenalectomy for benign adrenal tumors, focusing on the relationship between the number of surgeries and complication rates per facility.

Methods: Data were obtained from the Diagnosis Procedure Combination database, covering surgeries performed between April 2012 and March 2020. The inclusion criteria were laparoscopic adrenalectomy for benign adrenal tumors.

Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.

Diffusion-weighted imaging (DWI) has been frequently used to examine age-related deterioration of white matter microstructure and its relationship to cognitive decline. However, typical tensor-based analytical approaches are often difficult to interpret due to the challenge of decomposing and (mis)interpreting the impact of crossing fibers within a voxel. We hypothesized that a novel analytical approach capable of resolving fiber-specific changes within each voxel (i.

Application of high-quality targeted temperature management guided by multimodal brain monitoring in brain protection of patients with cardiac arrest: A case series.

Rationale: Cardiac arrest (CA) is an acute emergency with high mortality and is closely associated with the risk of brain damage or systemic ischemia-reperfusion injury, post-traumatic stress symptoms.

Patient Concerns: Targeted temperature management in the intensive care unit can improve the neurological outcomes of patients who are comatose after resuscitation from CA. However, there is often a lack of specific evaluation methods for optimal target temperature settings.

The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.

Orally bioavailable, synthetic nonpeptide agonists (NPAs) of the glucagon-like peptide-1 receptor (GLP-1R) may offer an effective, scalable pharmacotherapy to address the metabolic disease epidemic. One of the first molecules in the emerging class of GLP-1R NPAs is orforglipron, which is in clinical development for treating type 2 diabetes and obesity. Here, we characterized the pharmacological properties of orforglipron in comparison with peptide-based GLP-1R agonists and other NPAs.

Unlocking the Potential of Keratin: A Comprehensive Exploration from Extraction and Structural Properties to Cross-Disciplinary Applications.

The rapid expansion of the livestock and poultry industry has led to a considerable increase in slaughter byproducts; however, exploring their potential applications still needs to be improved. These underutilized byproducts, which include nails, hides, skins, and bones, represent a significant loss of valuable biological resources. Among these materials, keratin has garnered considerable attention due to its unique properties as a natural biopolymer.

Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in Systemic Lupus Erythematosus.

Objective: We aim to explore the role of mechanistic target of rapamycin complex (mTORC) 2 in systemic lupus erythematosus (SLE) development, the in vivo regulation of mTORC2 by type I interferon (IFN) signaling in autoimmunity, and to use mTORC2 targeting therapy to ameliorate lupus-like symptoms in an in vivo lupus mouse model and an in vitro coculture model using human PBMCs.

Method: We first induced lupus-like disease in T cell specific Rictor, a key component of mTORC2, deficient mice by topical application of imiquimod (IMQ) and monitored disease development. Next, we investigated the changes of mTORC2 signaling and immunological phenotypes in type I IFNAR deficient Lpr mice.

Multidimensional stress and self-harm in Chinese preadolescents: A cross-sectional study.

Background: Limited research has been conducted on self-harm among preadolescents in China. This study investigated the influence of multidimensional stress on high levels of self-harm behavior in preadolescents.

Method: This large-scale cross-sectional study of 7-14-year-old primary school students in grades 3-6 was conducted in Southwest China between September and December 2020.

Discrimination of wheat gluten quality utilizing terahertz time-domain spectroscopy (THz-TDS).

Wheat is an important food crop in the world, and wheat gluten quality is one of the important standards for judging the use of wheat. In this study, a combination of chemometric and machine learning methods based on THz-TDS were used to identify three different gluten wheats (high gluten, medium gluten, and low gluten). After collecting the time-domain spectral information of the samples, the frequency-domain spectra, refractive index spectra and absorption coefficient spectra of the samples were obtained by calculating the optical parameters.

Two types of microorganisms isolated from petroleum hydrocarbon pollutants: Degradation characteristics and metabolic pathways analysis of petroleum hydrocarbons.

The petroleum hydrocarbons in seawater have been worldwide concern contaminants. Biological method, with the advantages of low cost, minimal environmental impact, and no secondary pollution, is a promising method for petroleum hydrocarbon treatment. In this study, two strains, identified as Stenotrophomonas acidaminiphila and Ochrobactrum, were demonstrated to possess the ability to degrade petroleum hydrocarbons.

Targeting oncogenic transcriptional factor c-myc by oligonucleotide PROTAC for the treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, but effective therapeutic strategies are limited. Transcriptional factor c-Myc plays an oncogenic role in tumorigenesis and is an attractive target for HCC treatment. However, targeted therapy against c-Myc remains challenging.

Storage deterioration and detection of egg multi-scale structure: A review.

This review summarized the processes and mechanisms of deterioration in different components of eggs during storage. The mechanisms linked to reduced glycosylation, structural decay, and ovomucin degradation during egg-white thinning were elucidated, along with the weakening of lysozyme-ovomucin interactions. The degradation and S-conformation transformation of ovalbumin were studied, and the potential application of solubility-viscosity theory in egg-white thinning was discussed.

High-performance bacterium-enhanced dual-compartment microbial fuel cells for simultaneous treatment of food waste oil and copper-containing wastewater.

Microbial fuel cells (MFCs) use the metabolic actions of microorganisms in an anode chamber to convert the chemical energy from wastewater into electrical energy. To improve the MFC power generation performance and chemical oxygen demand (COD) removal efficiency, Stenotrophomonas acidaminiphila was added to the anode chamber of a dual-compartment MFC. In this process, Stenotrophomonas acidaminiphila promotes the degradation of macromolecules such as bis(2-ethylhexyl) phthalate in food waste oil.

Light-chain amyloidosis with dysphagia as the main symptom: a case report.

Background: Immunoglobulin light-chain amyloidosis is a relatively rare condition with a worldwide incidence of 5.1-12.8 cases per million person-years (Baker, 2022).

Physical activity and frontoparietal network connectivity in traumatic brain injury.

Background: Prolonged changes to functional network connectivity as a result of a traumatic brain injury (TBI) may relate to long-term cognitive complaints reported by TBI survivors. No interventions have proven to be effective at treating long-term cognitive complaints after TBI but physical activity has been shown to promote cognitive function and modulate functional network connectivity in non-injured adults. Therefore, the objective of this study was to test if physical activity engagement was associated with functional connectivity of the cognitively relevant frontoparietal control network (FPCN) in adults with a TBI history.

Exogenous salicylic acid treatment enhances the disease resistance of by regulating secondary metabolite production.

Introduction: Salicylic acid (SA) is a phenolic compound widely found in plants. It plays a key role in exerting plant disease resistance. Ha & Grushv.