Estimating the effect of biological nitrification inhibition-enabled sorghum on nitrogen fertilizer consumption, life cycle GHG emissions, farmer's benefit and fertilizer subsidy from Indian sorghum production.

Biological nitrification inhibition (BNI) effectively curtails nitrogen (N) loss and enhances N utilization efficiency. BNI is increasingly important as a technology for mitigating greenhouse gas emissions and water pollution in countries with high N fertilizer consumption. This study aimed to evaluate the potential impacts of BNI-enabled sorghum varieties with a 30 % soil nitrification inhibition rate for a major sorghum-growing state (Maharashtra, India).

Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs.

Host cell proteins (HCPs) are one of the process-related impurities that need to be well characterized and controlled throughout biomanufacturing processes to assure the quality, safety, and efficacy of monoclonal antibodies (mAbs) and other protein-based biopharmaceuticals. Although ELISA remains the gold standard method for quantification of total HCPs, it lacks the specificity and coverage to identify and quantify individual HCPs. As a complementary method to ELISA, the LC-MS/MS method has emerged as a powerful tool to identify and profile individual HCPs during the downstream purification process.

A synthesis of the evidence regarding the efficacy of alternative field management practices in rice cultivation using life cycle assessment.

Field management practices are an important factor in mitigating climate change and increasing agricultural production. However, no study has synthesized the evidence on the efficacy of alternative field management practices and reviewed life cycle assessments that consider all emissions over the entire or part of the life cycle of rice production. Thus, 68 papers were reviewed and grouped into 13 field management categories.

Double immunofluorescence staining of whole-mount small intestinal mucosa samples as a tool for characterization of three-dimensional paratuberculosis granulomas.

Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (Map). The progression of PTB from subclinical to the clinical stage of the disease is determined locally at the level of the granuloma, a host defence hallmark against mycobacterial infection.

An ex ante life cycle assessment of wheat with high biological nitrification inhibition capacity.

It is essential to increase food production to meet the projected population increase while reducing environmental loads. Biological nitrification inhibition (BNI)-enabled wheat genetic stocks are under development through chromosome engineering by transferring chromosomal regions carrying the BNI trait from a wild relative (Leymus racemosus (Lam.) Tzvelev) into elite wheat varieties; field evaluation of these newly developed BNI-wheat varieties has started.

Cesarean Scar Ectopic Pregnancy-Case Series: Treatment Decision Algorithm and Success with Medical Treatment.

: Cesarean scar ectopic pregnancies are a rare form of extrauterine pregnancies, yet their incidence has increased along with the rise in the number of cesarean deliveries. As with other ectopic pregnancies, cesarean scar ectopic pregnancies pose a greater risk for maternal hemorrhage and ultimately maternal mortality. : We present a series of clinical cases of cesarean scar ectopic pregnancy diagnosed by transvaginal ultrasonography.

Assessment of new functional units for agrivoltaic systems.

In agrivoltaic systems, photovoltaic (PV) modules are ground-mounted between crops replacing a part of greenhouse or are set below or above the cover film of greenhouse; these can provide solutions with respect to land competition and climate change mitigation. These systems have certain additional functions, namely, sunlight sharing, land sharing and power generation, as compared to the conventional agricultural production systems. These new functions are not adequately performed by traditionally used functional units (FUs), such as the mass- or the area-based FU, in agricultural life cycle assessment (LCA).

Estimation of total CH emission from Japanese rice paddies using a new estimation method based on the DNDC-Rice simulation model.

Methane (CH) is a greenhouse gas, and paddy fields are one of its main anthropogenic sources. In Japan, country-specific emission factors (EFs) have been applied since 2003 to estimate national-scale CH emission from paddy field. However, these EFs did not consider the effects of factors that influence CH emission (e.

A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer.

Introduction: The aim of this study was to compare TOMOX versus FOLFOX4 as first-line treatment of advanced colorectal cancer (CRC).

Materials And Methods: 191 chemotherapy-naïve patients were randomized to receive TOMOX or FOLFOX4. Patients were evaluated every 3 months and chemotherapy was continued until disease progression or unacceptable toxicity.