Publications by authors named "Ai Kagase"

Background: The Direct Oral Anticoagulant (DOAC) Score can predict bleeding risk in patients with atrial fibrillation taking DOACs; however, it lacks external validation. Therefore, this study aimed to assess the association between the DOAC Score and bleeding events in patients with atrial fibrillation who underwent transcatheter aortic valve replacement.

Methods And Results: This retrospective multicenter cohort study included patients with atrial fibrillation who underwent transcatheter aortic valve replacement, as registered in a Japanese multicenter registry.

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Background: The Clinical Frailty Scale (CFS) is a useful frailty marker for predicting clinical outcomes in patients undergoing invasive therapy. However, the clinical impact of CFS after transcatheter edge-to-edge repair in patients with mitral regurgitation (MR) remains unclear. This study aimed to elucidate the association between the baseline frail status defined by the CFS and clinical outcomes with or without postprocedural MR ≥2+ (post-MR ≥2+) after transcatheter edge-to-edge repair.

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Sodium-glucose cotransporter 2 inhibitors have demonstrated positive effects in heart failure (HF) patients. However, the effects of dapagliflozin in patients with decompensated HF remain unclear. This study aimed to compare the efficacy and safety of early and late dapagliflozin administration for decompensated HF.

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Purpose: The skin perfusion pressure (SPP) increases after endovascular treatment (EVT) for up to 1 month, although changes beyond 1 month remain unreported. This study aimed to investigate the changes in the SPP over time after EVT.

Materials And Methods: This was a single-center, prospective, observational study.

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Purpose: This study aimed to examine the feasibility and impact of extra-vascular ultrasound (EVUS)-guided intervention for infrapopliteal (IP) artery occlusive disease.

Materials And Methods: A retrospective analysis was performed using data collected from patients who underwent endovascular treatment (EVT) for IP artery occlusive disease between January 2018 and December 2020 at our institution. A total of 63 consecutive de novoocclusive lesions were compared according to the recanalization method utilized.

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Background: Transcatheter aortic valve replacement (TAVR)-related coronary artery obstruction prediction remains unsatisfactory despite high mortality and novel preventive therapies.

Objectives: This study sought to develop a predictive model for TAVR-related coronary obstruction in native aortic stenosis.

Methods: Preprocedure computed tomography and fluoroscopy images of patients in whom TAVR caused coronary artery obstruction were collected.

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Background: Data regarding the incidence, predictive factors, and clinical outcomes of post-transcatheter aortic valve replacement (TAVR) bleeding is limited in the Asian cohort.

Objectives: This study sought to assess the predictors and prognostic impact of post-TAVR late bleeding.

Methods: This study used the Japanese multicenter registry data to analyze 2,518 patients (mean age: 84.

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Frailty is strongly associated with poor short- and long-term prognoses in patients who undergo transcatheter aortic valve implantation (TAVI). However, limited data are available regarding the association between frailty and late bleeding events after TAVI. Of the 2,518 patients in the Japanese multicenter TAVI registry, 1371 patients with complete data on frailty parameters were analyzed.

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Article Synopsis
  • The study investigates the impact of arm circumference (AC) on the clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR), highlighting a lack of existing data on this anthropometric measurement.* -
  • It divides patients into low and high AC groups and finds that those with low AC demonstrate greater frailty, with a higher risk of mortality independently associated with low AC values (HR: 2.56).* -
  • The inclusion of AC in conventional survival prediction models improves accuracy in forecasting patient outcomes after TAVR, suggesting AC should be considered in treatment decisions.*
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Aims: This study investigated the prognostic value of plasma volume status (PVS) in patients who underwent transcatheter aortic valve replacement (TAVR).

Methods And Results: Plasma volume status was calculated in 2588 patients who underwent TAVR using data from the Japanese multicentre registry. All-cause mortality and heart failure hospitalization (HFH) within 2 years of TAVR were compared among the PVS quartiles (Q1, PVS < 5.

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Article Synopsis
  • The study investigates how characteristics of adipose tissue, specifically subcutaneous (SAT) and visceral (VAT), can predict clinical outcomes in patients undergoing transcatheter aortic valve replacement (TAVR).
  • Data was analyzed from 1,372 patients, revealing that low-volume SAT and VAT were linked to poorer outcomes, while high density of these tissues indicated higher mortality risks.
  • The findings suggest that evaluating adipose tissue characteristics via CT scans could be an important tool in assessing prognosis for TAVR patients.
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Background: Information on early to late-phase kidney damage in patients who underwent transcatheter aortic valve replacement (TAVR) is scarce. We aimed to identify the predictive factors for late kidney injury (LKI) at 1-year and patient prognosis beyond 1-year after TAVR.

Methods: We retrospectively reviewed 1,705 patients' data from the Japanese TAVR multicenter registry.

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