Publications by authors named "Ahu Izgi"
Biomed Pharmacother
September 2014
Article Synopsis
- Telomeres are protective caps at the ends of chromosomes, maintained by specific proteins that prevent DNA degradation and fusion; single-stranded telomere binding proteins, like hPOT1, are especially important for telomere elongation and interact with telomerase, the enzyme that adds telomeric repeats to chromosomes.
- The TRAP assay is a highly sensitive method for detecting telomerase activity in cancer cells, revealing that all tumor tissues tested were telomerase-positive, while corresponding normal tissues were negative.
- The study found connections between telomerase activity and various clinical aspects of colorectal cancer, such as tumor stage and metastasis, although the expression levels of hPOT1 did not show significant differences across these findings compared to
