CXCL14 and miR-4484 serves as potential salivary biomarkers for early detection of peri-implantitis.

Peri-implantitis develops in 43.3% of implant patients, which affects tissues around the implant that may ultimately cause implant loss if not treated properly. Due to difficulties in detecting peri-implantitis in its early phases, implant failures are constantly on the rise.

Synthesis, molecular modeling investigation, molecular dynamic and ADME prediction of some novel Mannich bases derived from 1,2,4-triazole, and assessment of their anticancer activity.

A series of biologically active novel Mannich bases containing with a 1-1,2,4-triazole-5-one ring were developed to evaluate the cytotoxic activity. For this purpose, the synthesized Schiff Bases () were reacted with formaldehyde and morpholine, which is a secondary amine to yield novel -Mannich bases () the Mannich reaction. The structures of the compounds () were determined structurally employing H/C-NMR, IR and elemental analysis.

MiR-4484 Acts as a Potential Saliva Biomarker for Early Detection of Peri-implantitis.

Purpose: Peri-implantitis, a potentially progressive disease that occurs in patients with dental implants, is more aggressive than periodontal lesions, which makes the prevention of peri-implantitis an important priority. Due to problems in the early detection of peri-implantitis, there is an urgent need for discovering novel biologic molecules with the ability of early diagnosis. The goal of this study was to profile the microRNA content of saliva samples collected from patients with titanium-aluminum-vanadium alloy dental implants who experienced peri-implantitis and to find potential diagnostic markers for detection of this disease.

MicroRNA-145 transcriptionally regulates Semaphorin 3A expression in prostate cancer cells.

Prostate cancer (PCa) is one of the most prevalent cancer types among males. Differential expression of microRNAs is associated with various cancers including PCa. Although mature microRNAs are preferentially located in the cytoplasm, several studies identified mature human microRNAs in purified nuclei and miR-145 has been found to be predominantly expressed in the nuclei of benign tissues compared to tumor lesions.

Mode of action of carboplatin via activating p53/miR-145 axis in head and neck cancers.

Objectives: In this study, we aimed at investigating the expressions of miR-145 and its well-characterized direct targets on carboplatin treatment.

Study Design: Laboratory study.

Methods: The effect of carboplatin and miR-145 on the proliferative capacity of head and neck squamous cell carcinoma cells was evaluated using Cell Viability Detection Kit-8.

ING5 inhibits cancer aggressiveness by inhibiting Akt and activating p53 in prostate cancer.

Prostate cancer (PCa) is one of the most common types of cancer in men. In several recent studies, chromosomal deletions in the q arm of chromosome 2, where ING5 resides within, have been identified in various cancer types including PCa. In this study, we investigate the role of ING5 as a tumor suppressor in PCa.