Anomaly detection via Gumbel Noise Score Matching.

We propose Gumbel Noise Score Matching (GNSM), a novel unsupervised method to detect anomalies in categorical data. GNSM accomplishes this by estimating the scores, i.e.

Comparative efficacy of palliative radiotherapy dose schedules in advanced bladder cancer-associated gross hematuria.

Introduction: Gross hematuria (GH) in advanced/inoperable bladder cancer patients causes significant morbidity. Patients frequently need multiple transfusions. Hypofractionated radiotherapy (RT) has been shown to be effective in symptom palliation.

Absolute response of a proton detector composed of a microchannel plate assembly and a charge-coupled device to laser-accelerated multi-MeV protons.

The absolute response of a real-time proton detector, composed of a microchannel plate (MCP) assembly, an imaging lens, and a charge-coupled device (CCD) camera, is calibrated for the spectral characterization of laser-accelerated protons, using a Thomson parabola spectrometer (TPS). A slotted CR-39 plate was used as an absolute particle-counting detector in the TPS, simultaneously with the MCP-CCD detector to obtain a calibration factor (count/proton). In order to obtain the calibration factor as a function of proton energy for a wide range of proton numbers, the absolute response was investigated for different operation parameters of the MCP-CCD detector, such as MCP voltage, phosphor voltage, and CCD gain.

Calibration of radiochromic EBT3 film using laser-accelerated protons.

We present a proof of principle for onsite calibration of a radiochromic film (EBT3) using CR-39 as an absolute proton-counting detector and laser-accelerated protons as a calibration source. A special detector assembly composed of aluminum range filters, an EBT3 film, and a CR-39 detector is used to expose the EBT3 film with protons in an energy range of 3.65 MeV-5.

Investigation of Dielectric Properties of Polymers and their Discrimination Using Terahertz Time-Domain Spectroscopy with Principal Component Analysis.

Polymers are among the most commonly used materials in our everyday life. They are generally transparent to terahertz (THz) radiation, but are quite difficult to differentiate using optical techniques as few or no characteristic features exist in the spectral range of <2.0 THz for small and portable radiation systems.

Cutis verticis gyrata secondary to infiltrating ductal carcinoma breast.

Cutis verticis gyrata is a long lasting and progressive condition in which there is hypertrophy and folding of the scalp skin. It typically affects the vertex and occipital region; however, it may involve the entire scalp. Classically, it has been divided into primary and secondary forms.

An international consensus study of neuroleptic malignant syndrome diagnostic criteria using the Delphi method.

Objective: The lack of generally accepted diagnostic criteria for neuroleptic malignant syndrome (NMS) impedes research and clinical management of patients receiving antipsychotic medications. The purpose of this study was to develop NMS diagnostic criteria reflecting a broad consensus among clinical knowledge experts, represented by an international multispecialty physician panel.

Participants: Eleven psychiatrists, 2 neurologists, 2 anesthesiologists, and 2 emergency medicine specialists participated in a formal Delphi consensus procedure.

FLAG-IDA in the treatment of refractory/relapsed acute leukaemias: single centre study.

Objective: To evaluate the efficacy and toxicity profile of the combination of fludarabine, high dose cytarabine, idarubicin, and granulocyte colony stimulating factor in refractory relapsed cases of acute leukaemia, a study is being conducted at Armed Forces Bone Marrow Transplant Centre (AFBMTC) Rawalpindi since January 2003. Data up to June 2004 (early report) is being presented.

Methods: Twelve Patients with refractory/relapsed (Ref/Rel) acute leukaemia (AL) were treated with fludarabine 30 mg/m2 and cytosine arabinoside (AraC) Arac 2 g/m2 for 5 days, idarubicin 10 mg/m2 for 3 days, and granulocyte colony stimulating factor G-CSF 5 micro g/kg from day 0 till neutrophil recovery (ANC > 1.

Improvements in SSRI/SNRI-induced sexual dysfunction by switching to escitalopram.

Antidepressants, especially serotonin reuptake inhibiting agents, are associated with sexual dysfunction. The newest drug of this class, escitalopram, claims greater tolerability than older alternatives. This study evaluated patient experiences with switching from one serotonin enhancing antidepressant to escitalopram in individuals who already were complaining of antidepressant-induced sexual dysfunction.

Efficacy of letrozole for advanced breast cancer in postmenopausal patients.

Objective: To evaluate the clinical benefit and tolerability of letrozole after tamoxifen failure in locally advanced, recurrent or metastatic breast cancer in postmenopausal patients.

Design: A phase II non-randomized trial.

Place And Duration Of Study: Oncology Department, Combined Military Hospital, Rawalpindi, from March 1999 to February 2001 over a period of 2 years.

Toxicity profile and objective response of paclitaxel in metastatic breast cancer.

Objective: To evaluate the efficacy and toxicity of 1-hour weekly Paclitaxel in metastatic breast cancer along with evaluation of overall survival.

Design: A phase II interventional trial.

Place And Duration Of Study: Oncology Department, Combined Military Hospital, Rawalpindi, between August 2001 to July 2003.