Transcriptomics and metabonomics reveal molecular mechanisms promoting lipid production in Haematococcus pluvialis co-mutated by atmospheric and room temperature plasma with ethanol.

Atmospheric and room temperature plasma mutation and co-mutation with ethanol were employed to generate Haematococcus pluvialis mutants AV3 and AV8. These mutants were screened using multiple indices of chlorophyll fluorescence, quantum yield, lethality, growth rate, dry cell weight, and lipid content. Compared to the wild strain, the mutants demonstrated genetic stability (*p > 0.