[REGULATORY B CELLS].

B lymphocytes represent a major component of the immune system. In addition to their best understood functions, B cells have also been demonstrated to downregulate inflammatory reactions and induce tolerance. The general concept that B cells might have the ability to induce tolerance was already introduced in the 1970s.

Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss.

Different immune disorders are involved in the development of sudden sensorineural hearing loss (SSNHL). This includes a wide spectrum of immune-mediated disorders such as immune complexes, production of autoantibodies to the inner ear proteins, production of anticardiolipin (aCL) antibodies, and cellular immune defects. Some studies have also found an elevation of total IgE levels and a type 1 immune reaction.