Potential Inflammatory Markers Related to the Conversion to Alzheimer's Disease in Female Patients With Late-Life Depression.

Background: Inflammation has been postulated as a mediating factor in the development of Alzheimer's disease (AD) pathology. We investigated candidate inflammatory markers related to conversion to AD among patients with depression.

Methods: A longitudinal study was conducted with older women with depression who were at least 55 years of age, with a mean follow-up period of 5.

University students' experience of online space while engaging in synchronous learning videoconferencing amidst the pandemic.

Background: The high infectivity and fatality of COVID-19 has changed the mode of higher education from onsite to online. Although many studies investigated the effectiveness and satisfaction of online education, little is known regarding university students' lived experience of online space during synchronous learning videoconferencing.

Objective: The present study explored how university students experienced online space when engaging in synchronous learning videoconferencing platforms during the outbreak of the pandemic.

University students' career adaptability as a mediator between cognitive emotion regulation and career decision-making self-efficacy.

As modern society experiences rapid changes, the unpredictability of the labor market is increasing. University students preparing to join the workforce may experience increased anxiety and stress due to the heightened uncertainty regarding their career plans. Regulating such negative emotions and adjusting to the changing circumstances may influence their career development.

Text Mining Analysis of Korean University Students' Academic Coaching Intake Session Reports.

Academic coaching has been emphasized in Korean universities as an effective measure to assist students' academic achievement and success. To better assess the needs of the students, the current study investigated academic coaching intake session reports archived at a Korean university from January 2017 to August 2021 and examined students' descriptions of their academic concerns and barriers. The intake session reports were categorized according to (1) students' affiliated department tracks, namely Humanities and Social Science (HSS) and Science, Technology, Engineering, and Math (STEM) tracks, and (2) the time the coaching sessions took place, i.

Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable Self-Microemulsifying Drug Delivery System Containing Gelucire 44/14.

To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul MCM (oil), Tween 80 (surfactant), Transcutol P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but encountered a stability problem (Transcutol P-induced weight loss in storage) after solidification. In the present study, replacing Transcutol P with Gelucire 44/14 resulted in a novel SuSMED formulation, wherein the total amount of surfactant/cosurfactant was less than that of the previous formulation. Solidified SuSMED (S-SuSMED) granules were prepared by blending VST-containing SuSMED with selective solid carriers, L-HPC and Florite PS-10, wherein VST existed in an amorphous state.

Extracting information from free-text electronic patient records to identify practice-based evidence of the performance of coronary stents.

Background And Objective: Percutaneous coronary intervention (PCI) using drug-eluting stents (DES) is an indispensable treatment for coronary artery disease. However, to evaluate the performance of various types of stents for PCI, numerous resources are required. We extracted clinical information from free-text records and, using practice-based evidence, compared the efficacy of various DES.

Liquid chromatography-tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study.

Baclofen is a structural analogue of γ-aminobutyric acid (GABA) that has been used for the treatment of spasticity since 1977. This study describes a simple and sensitive LC/MS/MS assay for the quantification of baclofen in rat plasma, urine, as well as various tissue samples. The assay utilized a simple protein precipitation and achieved lower limit of quantification (LLOQ) of 0.

Influence of prescribed herbal and Western medicine on patients with abnormal liver function tests: a retrospective quasi-experimental study.

Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests.

Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal, western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted.