The slow pace of discovery of new effective drugs against multi-drug resistant pathogens and largely unsuccessful combinatorial chemistry has resulted in shifting the focus back to natural products as sources of lead molecules for antimicrobial drugs, mainly due to their structural diversity. Investigation of under-explored habitats for potentially novel microorganisms provides for wider chemodiversity. In this study, four actinomycetes, namely UK-274, UK-281, UK-282 and UK-285, which showed broad-spectrum antibacterial and antifungal activities, were isolated from Timli forest range of the biodiversity-rich Himalayan region.
View Article and Find Full Text PDFDuring a screening program for actinomycetes from underexplored and arid Thar Desert (India), TD-093 was isolated. The isolate was characterized based on 16S rDNA sequencing. Aqueous and organic solvent extracts of culture supernatant were investigated for antimicrobial activity.
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