Publications by authors named "Ahmet Varol"
Article Synopsis
- * The study tested an oral ferroportin inhibitor called vamifeport in a mouse model (C282Y) that mimics the most common genetic mutation in humans with hemochromatosis, finding that it effectively lowered iron levels in the bloodstream and liver.
- * Chronic treatment with vamifeport not only maintained lower iron levels but did so without hindering the effects of phlebotomy, suggesting it could be a viable therapy for hemochromatosis patients who undergo iron removal.
Article Synopsis
- T-cell responses require two signals for effective activation: engagement of T-cell receptors (signal 1) and additional costimulatory signals (signal 2), which T-cell bispecific antibodies (TCBs) can provide by targeting specific antigens and CD3ε.
- The study introduces CD19-CD28, a bispecific CD19-targeted CD28 agonist, designed to enhance the effectiveness of glofitamab, a TCB targeting malignant B cells, by delivering the crucial costimulatory signal 2 needed for stronger T-cell responses.
- Initial results show that combining glofitamab with CD19-CD28 and the 4-1BB agonist significantly improves long
Article Synopsis
- Diffuse large B cell lymphomas (DLBCL) are a common and complex form of Non Hodgkin Lymphoma, with a significant number of patients experiencing relapse despite treatment, highlighting the need for better therapies.
- CD20-TCB, a novel bi-specific antibody that targets T cells to attack DLBCL, shows promise by quickly forming stable interactions between T cells and tumor cells, which enhances anti-tumor effects.
- Research using advanced imaging techniques demonstrated that the effectiveness of CD20-TCB is linked to its ability to induce rapid synapse formation and recruit T cells from the body, and this process can be partially disrupted by blocking certain immune signaling pathways.
β-Thalassemia is a genetic anemia caused by partial or complete loss of β-globin synthesis, leading to ineffective erythropoiesis and RBCs with a short life span. Currently, there is no efficacious oral medication modifying anemia for patients with β-thalassemia. The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities.
View Article and Find Full Text PDFPrion infections cause neurodegeneration, which often goes along with oxidative stress. However, the cellular source of reactive oxygen species (ROS) and their pathogenetic significance are unclear. Here we analyzed the contribution of NOX2, a prominent NADPH oxidase, to prion diseases.
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