Quantitative assessment of volume-based metabolic parameters in early-stage invasive ductal breast cancer: Impact of different standardized uptake value thresholds on prognostic factors - A comprehensive analysis.

Objective: This study compares volume-based metabolic parameters in early-stage invasive ductal breast cancer using different standardized uptake value (SUV) thresholds and examines their association with immunohistochemical factors.

Subjects And Methods: A retrospective analysis included 135 patients with early-stage invasive ductal breast cancer who underwent preoperative fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) scans. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were derived using absolute SUV threshold methods and fixed % maximum tumor SUV threshold methods.

Analysis of Measles and Rubella Immunoglobulin G Titers in COVID-19 Patients.

Background: The objective of this study is to compare the measles immunoglobulin G (IgG) and rubella IgG levels in patient groups with mild and severe COVID-19 disease and reveal the possible relationship.

Methods: This study was conducted among COVID-19-confirmed patients over 18, under 65 years of age. This study involved 75 participants- divided into two groups.

Evaluation of brain metabolism using F18-FDG PET/CT imaging in patients diagnosed with lung cancer.

Objectives: Brain imaging of regional metabolic changes in cancer patients can provide insights into cancer biology. We aimed to detect regional metabolic changes in the brains of untreated lung cancer patients without brain metastases using 2-deoxy-2-[18F]fluoroglucose PET/computed tomography.

Methods: The study included 44 lung cancer patients and 17 non-cancer patients as controls.

Physics-Informed Graph Neural Networks to solve 1-D equations of blood flow.

Background And Objective: Computational models of hemodynamics can contribute to optimizing surgical plans, and improve our understanding of cardiovascular diseases. Recently, machine learning methods have become essential to reduce the computational cost of these models. In this study, we propose a method that integrates 1-D blood flow equations with Physics-Informed Graph Neural Networks (PIGNNs) to estimate the propagation of blood flow velocity and lumen area pulse waves along arteries.

Bone and Parathyroid Scintigraphy Findings in Sagliker Syndrome.

Sagliker syndrome (SS) is a rare, exaggerated form of chronic kidney disease (CKD)-mineral and bone disorder resulting from untreated secondary hyperparathyroidism due to CKD. Herein, we describe a 34-year-old male patient whose Tc-99m-methylene diphosphonate bone scintigraphy and Tc-99m-sestamibi parathyroid scintigraphy revealed hints of SS and exhibited its defining characteristics.

A data-driven computational methodology towards a pre-hospital Acute Ischaemic Stroke screening tool using haemodynamics waveforms.

Background And Objective: Acute Ischaemic Stroke (AIS), a significant global health concern, results from occlusions in cerebral arteries, causing irreversible brain damage. Different type of treatments exist depending on the size and location of the occlusion. Challenges persist in achieving faster diagnosis and treatment, which needs to happen in the first hours after the onset of symptoms to maximize the chances of patient recovery.

The effects of dexmedetomidine on trauma-induced secondary injury in rat brain.

Background: The objective of this study was to investigate the effect of dexmedetomidine (Dex), a sedative drug with little or no depressant effect on respiratory centers, on secondary injury in rat brain tissue by means of the Na+/K+ ATPase enzyme, which maintains the cell membrane ion gradient; malondialdehyde, an indicator of membrane lipid peroxidation; glutathione, an indicator of antioxidant capacity; and histopathological analyses.

Methods: Eighteen rats were randomized into three groups: the trauma group received anesthesia, followed by head trauma with a Mild Traumatic Brain Injury Apparatus; the Trauma+Dex group received an additional treatment of 100 µg/kg intraperitoneal dexmedetomidine daily for three days; the Control group received anesthesia only.

Results: The highest MDA levels compared to the Control group were found in the Trauma group.

F-FDG PET/CT Findings Overlapping Lymphoma in a Patient with Systemic Juvenile Idiopathic Arthritis.

Systemic juvenile idiopathic arthritis (sJIA) is an important autoinflammatory disease whose first symptom is usually fever, and life-threatening conditions such as macrophage activation syndrome can develop when diagnosis and treatment is delayed. sJIA is an exclusion diagnosis, and there is no specific test that distinguishes it from other febrile diseases. We report the positron emission tomography/computed tomography (PET/CT) findings of sJIA in a 12-year-old girl who presented with fever, rash, and arthralgia.

Prediction of osteoporotic degradation of tibia human bone at trabecular scale.

A theoretical numerical model is proposed to predict patient dependent osteoporotic bone degradation. The model parameters are identified through a particle swarm optimization algorithm and based on individual patient high resolution peripherical quantitative computer tomography (HRpQCT) scan data. The degradation model is based on cellular activity initiated by the elastic strain energy developed in the bone microstructure through patient's body weight.

Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury.

Traumatic brain injury may trigger the secondary brain injury, which has the potential to be reversible and thus preventable. Anthocyanins are phylotherapeutic plants, which are reported to exhibit anti-inflammatory properties. This study aimed to evaluate the therapeutic efficiency of an anthocyanin, namely Vaccinium myrtillus, to alleviate secondary brain injury and identify possible mechanism of actions.

Biomechanical analysis of odontoid and transverse atlantal ligament in humans with ponticulus posticus variation under different loading conditions: Finite element study.

Purpose: Ponticulus posticus (PP) is a variation of the bone bridge that appears in the first cervical vertebra and through which the vertebral artery passes. Odontoid fractures are common spinal bone fractures in older people. This study aims to investigate the effect of neck movements on the odontoid and transverse atlantal ligament (TAL) of people with PP variation from a biomechanical view.

A Rare Case of Pulmonary Alveolar Microlithiasis with Diffuse Lung Uptake on Bone Scintigraphy.

Pulmonary alveolar microlithiasis is a rare disease characterized by accumulating intraalveolar small calcium phosphate stones. The disease is slow and does not show any signs in the early stages, but the shortness of breath, cough, and right heart failure may develop as it progresses. Methylene diphosphonate used in bone scintigraphy shows high uptake of calcium deposits in the alveoli and causes diffuse increased radiopharmaceutical uptake in the lungs.

SARS-CoV-2 specific antibody responses in healthcare workers after a third booster dose of CoronaVac or BNT162b2 vaccine.

The first SARS-CoV-2 vaccination campaign in Turkey has started in mid-January for the healthcare workers (HCWs) with the inactive virus vaccine CoronaVac (Sinovac). After four and a half months, the Turkish Ministry of Health rolled out a booster-dose vaccination campaign for HCWs and all people over 50 years old beginning in July 2021. The individuals eligible were given the choice of either CoronaVac or mRNA vaccine BNT162b2 for the third booster-dose vaccination.

Protective effect of thymoquinone in preventing trauma-related damage: an experimental study.

Background: Secondary injury is a potentially modifiable factor of outcome in traumatic brain injury. This study aimed to investigate thymoquinone's effects on trauma-induced neuronal damage.

Methods: Eighteen adult female Sprague-Dawley rats were assigned into three groups following ketamine and xylazine anaesthesia ( = 6): Control, Trauma, Trauma + Thymoquinone.

The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model.

In this study, we aimed to evaluate the hepatic protective effects of dexmedetomidine in the lower extremity ischemia-reperfusion model in diabetic rats biochemically and histopathologically. Rats were randomly divided into 4 equal groups (n = 6); Control (C) group, diabetic control group (DM), diabetic ischemia-reperfusion group (IR), group with diabetic IR and dexmedetomidine (DEX). In the IR and DEX groups were performed 120 min reperfusion after 120 min ischemia.

Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study.

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).

Objectives: Investigate the relationship between ACE I/D polymorphism and the clinical severity of COVID-19.

Design: Prospective cohort study.

Can Dexmedetomidine Be Effective in the Protection of Radiotherapy-Induced Brain Damage in the Rat?

Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, investigated the potential adverse effects of RT on the brain, using cognitive, histopathological, and biochemical methods, and the counteractive effect of the α2-adrenergic receptor agonist dexmedetomidine.

Evaluation of P-wave dispersion in patients with newly diagnosed coronavirus disease 2019.

Aim: The aim of the current study was to evaluate P-wave dispersion (PWD) as a predictor of atrial fibrillation in patients with newly diagnosed COVID-19. In addition, the relationship between the PWD and inflammation parameters was investigated.

Methods: A total of 140 newly diagnosed COVID-19 patients and 140 age- and sex-matched healthy individuals were included in the study.

Association of Mild Hyperbilirubinemia with Decreased ECG-Based Ventricular Repolarization Parameters in Young Men.

Objective: Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters.

Methods: We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2).

Evaluation of electrocardiographic ventricular repolarization variables in patients with newly diagnosed COVID-19.

Introduction: Coronavirus disease 2019 (COVID-19) is a newly recognized infectious disease that has spread rapidly. COVID-19 has been associated with a number of cardiovascular complications, including arrhythmias. The mechanism of ventricular arrhythmias in patients with COVID-19 is uncertain.

Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors.

Inhibition of aromatase enzymes is very important in the prevention of estrogen-related diseases and the regulation of estrogen levels. Aromatase enzyme is involved in the final stage of the biosynthesis of estrogen, in the conversion of androgens to estrogen. The development of new compounds for the inhibition of aromatase enzymes is an important area for medicinal chemists in this respect.

"Hot Lung" Sign in Pulmonary Intravascular Large B-Cell Lymphoma on 18F-FDG PET/CT.

Intravascular large B-cell lymphoma is a rare type of non-Hodgkin lymphoma characterized by intravascular proliferation of clonal lymphocytes within the lumen of small vessels, which is often fatal. Diffuse FDG uptake in the lung without clear/evident CT findings, "hot lung," is quasi-pathognomonic for lung intravascular large B-cell lymphoma. In this report, we present the case of a 43-year-old man who was diagnosed as having intravascular lymphoma thanks to this rare finding.

Titanium acetabular cementless cups combined with highly crosslinked polyethylene liner have very low rates of aseptic loosening.

Background: There is a clear tendency towards cementless acetabular components in primary total hip arthroplasty.

Objective: The aim of this study was to assess the long-term clinical and radiological outcome of titanium cementless acetabular cups when combined with a highly crosslinked polyethylene liner.

Methods: This study is a retrospective follow-up of 67 cups in 64 patients.