Publications by authors named "Ahmet S Bozkurt"
Background: Exosomes (Exos) are candidates for functional recovery and regeneration following sciatic nerve crushed (SNC) injury due to their composition which can accelerate tissue regeneration. Therefore, mouse embryonic fibroblast-derived exosomes were evaluated for their regenerative capacity in SNC injury.
Methods And Results: In the study, 40 Balb/c males (20 ± 5 g) and two pregnant mice (for embryonic fibroblast tissue) were used and crushed injury was induced in the left sciatic nerve with an aneurysm clamp.
Background: Injury systemically disrupts the homeostatic balance and can cause organ failure. LF mediates both iron-dependent and iron-independent mechanisms, and the role of LF in regulating iron homeostasis is vital in terms of metabolism.
Objectives: In this study, we evaluated the organ-level effect and gene expression change of bLf in the cutaneous repair process.
Objective: Obesity is a chronic multisystem disease associated with increased morbidity and mortality. Obesity, which is a complex, multifactorial, and heterogeneous condition, is thought to result from the interaction of environmental, physiological, and genetic factors. In this study, the relationship between serum levels of hemoglobin A1c, mucin-1, and nuclear factor κB in obese and healthy cohorts was evaluated along with biochemical and gene expressions and with demographic and clinical covariates, and their effects on obesity were evaluated.
View Article and Find Full Text PDFObjective: To investigate the effects of tocilizumab (TCZ), epoetin beta (EPO), and their combination on nerve regeneration in a sciatic nerve injury model.
Materials And Method: Male Sprague-Dawley rats were divided into (-) negative control, sham, TCZ, EPO ((+) positive control), and TCZ+EPO groups. The TCZ group received TCZ (8 mg/kg intraperitoneal) immediately after surgery.
Background: Epilepsy is a neurological disease characterized by recurrent seizures, hyperexcitable neurons and various behavioral comorbidities. The electrical charge during seizures depletes the antioxidant defense mechanism in the epileptic brain and increases the oxidative burden. Natural antioxidant compounds are potential therapeutics in the treatment of two major pathologies of epilepsy with their anticonvulsant and anxiolytic effects and can modulate these targets.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease (AD) is marked by neurodegeneration largely driven by hyperphosphorylated tau and amyloid-β toxicity, but recent studies are highlighting ferroptosis as a key contributor to the disease's progression.
- This study explores the potential of betulin, a triterpene from birch trees with antioxidant properties, in treating AD through its interaction with ISM1, an adipokine involved in neuroprotection.
- Results indicate that betulin may mitigate neuronal ferroptosis by regulating ISM1 and reducing iron accumulation, showing promise for cognitive improvement and overall antioxidant capacity in an AD model.
Histopathological efficacy of tacrolimus in an experimental head trauma study.
Ulus Travma Acil Cerrahi Derg
February 2023
Background: This study aimed to investigate the protective effect of tacrolimus (FK506), an immunosuppressive agent, on secondary brain damage in rats with experimental head trauma.
Methods: 40 Sprague-Dawley rats, aged 10-12 weeks and weighing 250-350 g, were used without gender selection. The subjects that were divided into five groups of 8 rats per group (sham control, negative control, positive control, vehicle control, and treatment) were sacrificed 1 month after head trauma was induced under appropriate conditions, their brains were then removed en bloc and evaluated histopathologically.
Article Synopsis
- The study explored how Extracellular Vesicles (EV) from mouse embryonic fibroblasts affect wound healing in diabetic mice, utilizing both lab and live mouse experiments.
- EV isolated from the fibroblasts improved levels of key healing-related biomarkers like VEGF, IL-6, and TNF-α, enhancing blood vessel formation (angiogenesis) in the wound area.
- Results suggested that these EVs not only speed up wound healing in diabetes but also improve the delivery of crucial cells, oxygen, and nutrients to the damaged tissue.
Ethnopharmacological Relevance: Ferula elaeochytris Korovin (FE) is a perennial medicinal plant of Apiaceae family. Ferula elaeochytris Korovin, known as 'Çakşır' in Anatolia, is widely used as an aphrodisiac as well as antioxidant, anti-inflammatory, and anti-diabetic.
Aim Of The Study: Erectile dysfunction (ED) is a serious public health problem that has a high prevalence and negatively affects the quality of life in elderly men.