Automated prescription of an optimal imaging plane for measurement of cerebral blood flow by phase contrast magnetic resonance imaging.

This study describes and evaluates a semiautomated method for prescribing an optimal imaging plane that is located as close as possible to the skull base, and is simultaneously nearly perpendicular to the four arteries leading blood to the brain [internal carotid arteries (ICAs) and vertebral arteries (VAs)]. Such a method will streamline and improve reliability of the measurement of total cerebral blood flow and intracranial pressure by velocity encoding phase-contrast magnetic resonance imaging. The method first extracts the vessels' centerline from a 2-D time-of-flight magnetic resonance angiogram of the neck by performing distance transformations.

Thickness profiles of retinal layers by optical coherence tomography image segmentation.

Purpose: To report an image segmentation algorithm that was developed to provide quantitative thickness measurement of six retinal layers in optical coherence tomography (OCT) images.

Design: Prospective cross-sectional study.

Methods: Imaging was performed with time- and spectral-domain OCT instruments in 15 and 10 normal healthy subjects, respectively.