Introducing a passively targeted formulation of diclofenac potassium for application in endodontics to minimize renal and gastrointestinal side effects.

This research aims to formulate, evaluate, and conduct a clinical investigation of mucoadhesive buccal discs of diclofenac potassium (DP) for application in endodontics to minimize side effects, mainly renal and gastrointestinal. The discs were compressed directly utilizing bioadhesive polymers like hydroxypropyl methylcellulose K4M (HPMC K4M), sodium carboxymethyl cellulose (NaCMC), Carbopol 934 (Cp934), methylcellulose (MC) and combinations of these polymers. In-vitro, release studies and ex-vivo and in-vivo determination of bioadhesion time were conducted.

Endoscopic interlaminar lumbar discectomy: How to decrease the learning curve.

Background: Herniated lumbar disc is a common cause of lumbosacral pain. Endoscopic interlaminar lumbar discectomy (ILD) is a well-established technique that provided comparable results to micro-discectomy. The aim of the study is to describe the learning curve of endoscopic ILD and explore measures that could improve effectiveness and decrease blood loss and operative time with accumulation of reasonable experience.

Growing skull fractures of the orbital roof: a multicentric experience with 28 patients.

Background: Growing skull fracture (GSF) is a rare condition that may complicate pediatric head trauma. Patients may present with delayed-onset neurological manifestations.

Aim: This study aims to highlight the different presentations, methods of evaluation, treatment modalities, and outcomes in patients with orbital roof GSF.

Age, gender and tumour size predict work capacity after surgical treatment of vestibular schwannomas.

Aims: The aim of the present study was to identify predictive factors for outcome after surgery of vestibular schwannomas.

Design: This is a retrospective study with partially collected prospective data of patients who were surgically treated for vestibular schwannomas at a single institution from 1979 to 2000. Patients with recurrent tumours, NF2 and those incapable of answering questionnaires were excluded from the study.