Recent metaheuristic algorithms for solving some civil engineering optimization problems.

In this study, a novel hybrid metaheuristic algorithm, termed (BES-GO), is proposed for solving benchmark structural design optimization problems, including welded beam design, three-bar truss system optimization, minimizing vertical deflection in an I-beam, optimizing the cost of tubular columns, and minimizing the weight of cantilever beams. The performance of the proposed BES-GO algorithm was compared with ten state-of-the-art metaheuristic algorithms: Bald Eagle Search (BES), Growth Optimizer (GO), Ant Lion Optimizer, Tuna Swarm Optimization, Tunicate Swarm Algorithm, Harris Hawk Optimization, Artificial Gorilla Troops Optimizer, Dingo Optimizer, Particle Swarm Optimization, and Grey Wolf Optimizer. The hybrid algorithm leverages the strengths of both BES and GO techniques to enhance search capabilities and convergence rates.

Development and validation of an UPLC-ESI-MS/MS method for quantification of duvelisib in plasma: application to pharmacokinetic study in rats.

Duvelisib (DUV) is a new oral phosphoinositide-3-kinase (PI3K)-δ and PI3K-γ inhibitor. It is used for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). This study describes the development and validation of a new highly sensitive and efficient UPLC-ESI-MS/MS method for quantitation of DUV in plasma samples and its application to the pharmacokinetic study of DUV in rats.

Synthesis, spectroscopic and computational studies on hydrogen bonded charge transfer complex of duvelisib with chloranilic acid: Application to development of novel 96-microwell spectrophotometric assay.

Duvelisib (DUV) is a is a small-molecule with inhibitory action for phosphoinositide 3-kinase (PI3K). It has been recently approved for the effective treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Novel charge transfer complex (CTC) between DUV, as electron donor, with chloranilic acid (CLA), as π electron acceptor has been synthesized and characterized using different spectroscopic and thermogravimetric techniques.

A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats.

Background: Duvelisib (DUV) is a new oral phosphoinositide-3-kinase (PI3K)-δ and PI3K-γ inhibitor. It has been recently granted an accelerated approval for treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It is also effective in therapy of T-cell lymphoma, solid tumors, and non-Hodgkin's lymphoma.

Innovative use of σ and π electron acceptors in the development of three high throughput 96-microwell spectrophotometric assays for crizotinib.

Crizotinib (CZT) is a potent and selective tyrosine kinase inhibitor used for treatment of non-small cell lung cancer (NSCLC). The development of high-throughput assays for its quality control (QC) is very essential to assure its therapeutic benefits. CZT molecule has multiple electron-donating atoms that can contribute to the formation of colored charge-transfer (CT) complex with iodine as σ-electron acceptor and with 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (CHBQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-electron acceptors.

Fully Automated Approach for Early Detection of Pigmented Skin Lesion Diagnosis Using ABCD.

Computerized analysis of pigmented skin lesions (PSLs) is a lively space of survey that dates back over 25 years. Recently, different automated computer-based systems stand to be a helpful tool. Physicians' usage for ABCD worldwide as the main tool of diagnosis and self-examination make it the common reference for different skin cancer diagnosis models.