Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma.

Background: Radiotherapy treatment of head and neck cancer affects local arteries and increases the risk of stroke. This study aimed at a closer characterization of this damage and its development in time with a longitudinal study set up.

Methods: Male patients treated between 2011 and 2016 for hypopharyngeal carcinoma were identified from the in-house clinical data base.

Tumor grading of soft tissue sarcomas using MRI-based radiomics.

Background: Treatment decisions for multimodal therapy in soft tissue sarcoma (STS) patients greatly depend on the differentiation between low-grade and high-grade tumors. We developed MRI-based radiomics grading models for the differentiation between low-grade (G1) and high-grade (G2/G3) STS.

Methods: The study was registered at ClinicalTrials.

CT-based radiomic features predict tumor grading and have prognostic value in patients with soft tissue sarcomas treated with neoadjuvant radiation therapy.

Purpose: In soft tissue sarcoma (STS) patients systemic progression and survival remain comparably low despite low local recurrence rates. In this work, we investigated whether quantitative imaging features ("radiomics") of radiotherapy planning CT-scans carry a prognostic value for pre-therapeutic risk assessment.

Methods: CT-scans, tumor grade, and clinical information were collected from three independent retrospective cohorts of 83 (TUM), 87 (UW) and 51 (McGill) STS patients, respectively.