Adverse effects of heat shock in rice ( L.) and approaches to mitigate it for sustainable rice production under the changing climate: A comprehensive review.

Heat shock, a transient exposure to high temperatures, is a substantial hazard to rice ( L.) production and sustainability. The objective of this review paper is to summarize the impact of heat shock on rice and explore approaches to mitigate its adverse effects to achieve sustainable production.

Identification of VISTA regulators in macrophages mediating cancer cell survival.

Numerous human cancers have exhibited the ability to elude immune checkpoint blockade (ICB) therapies. This type of resistance can be mediated by immune-suppressive macrophages that limit antitumor immunity in the tumor microenvironment (TME). Here, we elucidate a strategy to shift macrophages into a proinflammatory state that down-regulates V domain immunoglobulin suppressor of T cell activation (VISTA) via inhibiting AhR and IRAK1.

Projections of future bioclimatic indicators using bias-corrected CMIP6 models: a case study in a tropical monsoon region.

This study evaluates the potential impacts of climate change on Bangladesh by analyzing 19 bioclimatic indicators based on temperature and precipitation. Data from 18 bias-corrected CMIP6 global climate models (GCMs) were used, covering four Shared Socioeconomic Pathways (SSPs)-SSP126, SSP245, SSP370, and SSP585-across three future timeframes: near-term (2015-2044), mid-term (2045-2074), and long-term (2075-2100). Under the high-emission SSP585 scenario, average temperatures are projected to rise by up to 3.

The DIAD Approach to Correlative Synchrotron X-ray Imaging and Diffraction Analysis of Human Enamel.

The Dual Imaging and Diffraction (DIAD) beamline at Diamond Light Source (Didcot, U.K.) implements a correlative approach to the dynamic study of materials based on concurrent analysis of identical sample locations using complementary X-ray modalities to reveal structural detail at various length scales.

Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2.

Alzheimer's disease (AD), a chronic neurodegenerative disorder, is the leading cause of dementia. Over-activated microglia is related to amyloid-beta (Aβ) and phosphorylated tau (phospho-tau) accumulation in the AD brain. Taurine is an amino acid with multiple physiological functions including anti-inflammatory effects, and has been reported to be neuroprotective in AD.

Band gap engineering in lead free halide cubic perovskites GaGeX (X = Cl, Br, and I) based on first-principles calculations.

Lead-free inorganic Ge-based perovskites GaGeX (X = Cl, Br, and I) are promising candidates for solar cell applications due to their structural, mechanical, electrical, and optical properties. In this work, we performed density functional theory (DFT) calculations using the CASTEP module to investigate these properties in detail. We found that the lattice parameters and cell volumes increase with the size of the halogen atoms, and that all the compounds are stable and ductile.

Superior Cyclic Stability and Capacitive Performance of Cation- and Water Molecule-Preintercalated δ-MnO/h-WO Nanostructures as Supercapacitor Electrodes.

The large number of active sites in the layered structure of δ-MnO with considerable interlayer spacing makes it an excellent candidate for ion storage. Unfortunately, the δ-MnO-based electrode has not yet attained the exceptional storage potential that it should demonstrate because of disappointing structural deterioration during periodic charging and discharging. Here, we represent that stable Na ion storage in δ-MnO may be triggered by the preintercalation of K ions and water molecules.

2D-2D Nanoheterostructure of an Exposed {001}-Facet CuO and MoS Based Bifunctional Catalyst Showing Excellent Surface Chemistry and Conductivity for Cathodic CO Reduction.

A novel CuO-MoS based heterostructure catalyst model system is proposed where a CuO nanosheet with exposed {001} facet with proper termination is the active surface for the catalysis and a MoS nanosheet is the supporting layer. Density functional theory (DFT) calculations were performed to validate the model. The MoS bilayer forms a stable heterostructure with {001} faceted CuO with different terminations exposing oxygen and copper atoms (active sites) on the surface.

Demographic and Clinical Characteristics of Persons With Spinal Cord Injury in Bangladesh: Database for the International Spinal Cord Injury Community Survey 2023.

The study aims to explore the demographic and clinical characteristics of persons with spinal cord injury (SCI) in Bangladesh. A total of 3035 persons with SCI spanning from 2018 to 2022 were included in this cross-sectional study. Information about demographic and clinical variables was obtained from the medical records and verified through telephone calls to ensure accuracy and consistency.

A magneto-activated nanoscale cytometry platform for molecular profiling of small extracellular vesicles.

Exosomal PD-L1 (exoPD-L1) has recently received significant attention as a biomarker predicting immunotherapeutic responses involving the PD1/PD-L1 pathway. However, current technologies for exosomal analysis rely primarily on bulk measurements that do not consider the heterogeneity found within exosomal subpopulations. Here, we present a nanoscale cytometry platform NanoEPIC, enabling phenotypic sorting and exoPD-L1 profiling from blood plasma.

Statistical Effective Diffusivity Estimation in Porous Media Using an Integrated On-site Imaging Workflow for Synchrotron Users.

Unlabelled: Transport in porous media plays an essential role for many physical, engineering, biological and environmental processes. Novel synchrotron imaging techniques and image-based models have enabled more robust quantification of geometric structures that influence transport through the pore space. However, image-based modelling is computationally expensive, and end users often require, while conducting imaging campaign, fast and agile bulk-scale effective parameter estimates that account for the pore-scale details.

Foliar application of enriched banana pseudostem sap influences the nutrient uptake, yield, and quality of sweet corn grown in an acidic soil.

Foliar fertilization is a reliable technique for correcting a nutrient deficiency in plants caused by inadequate nutrient supply to the roots in acid soil. Soluble nutrients in banana pseudostem sap might be effective to supplement chemical fertilizers. However, the limited nutrients in sole banana pseudostem sap as foliar fertilization may not meet-up the nutritional demand of the crop.

Rationalisation of laboratory tests ordering and consumption at Armed Forces Hospital, Jazan.

Laboratory testing is one of the major and important component of medical diagnosis. However, unrationalised laboratory test ordering may lead to misdiagnosis of diseases which would delay treatment of the patients. It would also lead to wasting the laboratory resources that adversely impact the hospital budget.

Exploring the Perception of Dental Undergraduate Students and Faculty on Environmental Sustainability in Dentistry: A Cross-Sectional Survey in 26 Dental Schools in Saudi Arabia.

There are few published studies assessing dental students' and faculty's perception regarding environmental sustainability in dentistry (ESD) and its existence within the dental curricula along with barriers and enablers for its integration. As far as the authors know, no published study has looked into this in Saudi Arabia, and this is what the current study aims to explore. A cross-sectional survey using validated online questionnaires for dental students and faculty was carried out in 26 dental schools in Saudi Arabia.

Vegetable Oil-Peroxidation Product 'Hydroxynonenal' Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver.

Hsp70.1 has a dual function as a chaperone protein and lysosomal stabilizer. In 2009, we reported that calpain-mediated cleavage of carbonylated Hsp70.

Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting.

The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is hindered by the need to obtain large and fresh tumour fractions, which is often not feasible in patients with unresectable tumours or recurrent metastases. Here we show that circulating tumour-reactive lymphocytes (cTRLs) can be isolated from peripheral blood at high yield and purity via microfluidic immunomagnetic cell sorting, allowing for comprehensive downstream analyses of these rare cells. We observed that CD103 is strongly expressed by the isolated cTRLs, and that in mice with subcutaneous tumours, tumour-infiltrating lymphocytes isolated from the tumours and rapidly expanded CD8CD103 cTRLs isolated from blood are comparably potent and respond similarly to immune checkpoint blockade.

Preliminary report on the comparative weed suppressibility of Bangladeshi Wheat varieties.

A key and ecologically sound strategy for integrated weed management is the use of varieties of weed-competitive crops. Utilizing wheat cultivars that are weed-competitive can lessen weed pressure and inordinate herbicide usage in wheat fields by a substantial amount. To assess the weed suppressibility of Bangladeshi wheat varieties, a field test was carried out in 2018 throughout the winter season at the Agronomy Field Laboratory, Bangladesh Agricultural University, Bangladesh.

Oxidative DNA Damage by N4-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir.

Molnupiravir is an antiviral agent recently used for treating coronavirus disease 2019 (COVID-19). Here, we demonstrate that N4-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA damage in isolated DNA. A colorimetric assay revealed hydroxylamine generation from CDA-treated NHC.

Seroprevalence of SARS-CoV-2 antibodies among Forcibly Displaced Myanmar Nationals in Cox's Bazar, Bangladesh 2020: a population-based cross-sectional study.

Objectives: The study aimed to determine the seroprevalence, the fraction of asymptomatic infections, and risk factors of SARS-CoV-2 infections among the Forcibly Displaced Myanmar Nationals (FDMNs).

Design: It was a population-based two-stage cross-sectional study at the level of households.

Setting: The study was conducted in December 2020 among household members of the FDMN population living in the 34 camps of Ukhia and Teknaf Upazila of Cox's Bazar district in Bangladesh.

Genome-wide in vivo screen of circulating tumor cells identifies as a regulator of metastasis.

Circulating tumor cells (CTCs) break free from primary tumors and travel through the circulation system to seed metastatic tumors, which are the major cause of death from cancer. The identification of the major genetic factors that enhance production and persistence of CTCs in the bloodstream at a whole genome level would enable more comprehensive molecular mechanisms of metastasis to be elucidated and the identification of novel therapeutic targets, but this remains a challenging task due to the heterogeneity and extreme rarity of CTCs. Here, we describe an in vivo genome-wide CRISPR knockout screen using CTCs directly isolated from a mouse xenograft.