Highlights in TMPRSS2 inhibition mechanism with guanidine derivatives approved drugs for COVID-19 treatment.

Transmembrane protease serine 2 (TMPRSS2) has been identified as a critical key for the entry of coronaviruses into human cells by cleaving and activating the spike protein of SARS-CoV-2. To block the TMPRSS2 function, 18 approved drugs, containing the guanidine group were tested against TMPRSS2's ectodomain (7MEQ). Among these drugs, Famotidine, Argatroban, Guanadrel and Guanethidine strongly binds with TMPRSS2 S1 pocket with estimated Fullfitness energies of -1847.

Autonomic and Cardiac Repolarization Lability in Long QT Syndrome Patients.

Objective: Long QT-Syndrome (LQTS) patients are at risk of arrhythmias and seizures. We investigated whether autonomic and cardiac repolarization measures differed based on LQTS genotypes, and in LQTS patients with vs. without arrhythmias and seizures.

Pr doping at the A-site of LaBaMnO nanocrystalline material: assessment of the relationship between structural and physical properties and Bean-Rodbell model simulation of disorder effects.

Bulk nanocrystalline samples of (La Pr )BaMnO (0.075 ≤ ≤ 0.30) manganites with a fixed carrier concentration are prepared by the sol-gel based Pechini method.

Bis(2-meth-oxy-benzyl-ammonium) di-aqua-bis-(di-hydrogen diphosphato-κ(2) O,O')cobaltate(II) dihydrate.

The title compound, (C8H12NO)2[Co(H2P2O7)2(H2O)2]·2H2O, crystallizes isotypically with its Mn(II) analogue. It consists of alternating layers of organic cations and inorganic complex anions, extending parallel to (100). The complex cobaltate(II) anion exhibits -1 symmetry.

Bis(2,6-di-methyl-anilinium) di-aqua-bis-(di-hydrogen diphosphato-κ(2) O,O')cobaltate(II).

In the title compound, (C8H12N)2[Co(H2P2O7)2(H2O)2], the Co(2+) ion lies on a crystallographic inversion centre and adopts a slightly distorted octa-hedral CoO6 coordination geometry arising from two chelating diphosphate [H2P2O7](2-) ligands and two trans water mol-ecules. In the crystal, the components are linked by O-H⋯O, N-H⋯O and C-H⋯O hydrogen bonds and weak aromatic π-π stacking [shortest centroid-centroid separation = 3.778 (2) Å] inter-actions.

Bis(2-methyl-anilinium) diaqua-bis[dihydrogendiphosphato(2-)]cobaltate(II).

In the title cobalt(II) complex with 2-methyl-anilinium and diphosphate, (C(7)H(10)N)(2)[Co(H(2)P(2)O(7))(2)(H(2)O)(2)], a three-dimensional network is built up from anionic layers of [Co(H(2)P(2)O(7))(2)(H(2)O)(2)](2-) units and 2-methyl-anilinium cations located between these layers. The dihydrogendiphosphate groups present a bent eclipsed conformation, while the Co(2+) ions lie on inversion centers. An intricate network of O-H⋯O and N-H⋯O hydrogen bonds is established between the different components, assuring the cohesion of the network with other inter-actions, being of electrostatic and van der Waals nature.