Cd(II) and Pd(II) Mixed Ligand Complexes of Dithiocarbamate and Tertiary Phosphine Ligands-Spectroscopic, Anti-Microbial, and Computational Studies.

Mixed ligand complexes of Pd(II) and Cd(II) with -picolyl-amine dithiocarbamate (PAC-dtc) as primary ligand and tertiary phosphine ligand as secondary ligands have been synthesized and characterized via elemental analysis, molar conductance, NMR (H and P), and IR techniques. The PAC-dtc ligand displayed in a monodentate fashion via sulfur atom whereas diphosphine ligands coordinated as a bidentate mode to afford a square planner around the Pd(II) ion or tetrahedral around the Cd(II) ion. Except for complexes [Cd(PAC-dtc)(dppe)] and [Cd(PAC-dtc)(PPh)], the prepared complexes showed significant antimicrobial activity when evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger.

Synthesis, structure and reactivity with phosphines of Hg(II) -cyano-aminothiophenolate complexes formed C-S bond cleavage and dehydrogenation of 2-aminobenzothiazoles.

Addition of 2-aminobenzothiazole (abt) and substituted derivatives to Hg(OAc) leads to the high yield formation of -cyano-aminothiophenolate (ocap) complexes [Hg{SCHXN(CN)}] (X = H, Me, Cl, Br, NO) resulting from dehydrogenation and C-S bond cleavage. The reaction appears to be unique to Hg(OAc) and with HgCl the product [HgCl(abt)] contains an intact abt ligand, but reacts with acetate to afford the ocap complex [Hg{SCHN(CN)}]. Binding of abt to Hg(II) has previously been probed in molecular structures of [Hg(sac)(abt)L] (L = MeOH, DMSO) and these have been reexamined to understand the perturbation of abt upon coordination.

Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase.

Ten transition metal dithiocarbamate (DTC)complexes of the type [M( -EtDT)] (), and [M( -PyDT)] () (where M = Co, Ni, Cu, Pd, and Pt; EtDT = diethyl dithiocarbamate; PyDT = pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species.

Synthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases.

New Schiff bases {N'-(phenyl(pyridin-2-yl)methylene) isonicotinohydrazide (LH), -(naphthalen-1-yl)- -(phenyl(pyridin-2-yl) methylidene) ethane-1,2-diamine (LH), N-(6-chlorobenzo[d]thiazol-2-yl)-1-phenyl-1-(pyridin-2-yl) methanimine (LH)}were synthesized by reaction of 2-benzoylpyridine with different amines (2-amino-6-chlorobenzothiazole, isonicotinohydrazide and -(naphthalen-1-yl)ethane-1,2-diamine) and characterized by H-NMR, C-NMR, IR mass spectroscopy and elemental analysis. The compounds were assayed by the disc diffusion method for anti-bacterial against five pathogenic bacteria species ( and ). All prepared Schiff bases showed good activity compared to positive control (streptomycin), Moreover the showed the highest activity against than the other compounds and streptomycin.

Formation of ortho-cyano-aminothiophenolate ligands with versatile binding modes via facile carbon-sulfur bond cleavage of 2-aminobenzothiazoles at mercury(II) centres.

Addition of 2-aminobenzothiazole and substituted derivatives to mercuric acetate in warm ethanol leads to the high yield formation of [Hg{SC6H3XN(C[triple bond, length as m-dash]N)}]n resulting from loss of hydrogen and sulfur-carbon bond cleavage. Addition of phosphines affords a series of complexes in which the new ortho-cyano-aminothiophenolate ligands adopt three different binding modes.