Induction and preliminary characterization of neoplastic pulmonary nodules in a transgenic pig model.

Objectives: Lung cancer models in large animals are lacking. Oncopigs are transgenic pigs that carry both KRAS and TP53 Cre-inducible mutations. This study aimed to develop and histologically characterize a swine model of lung cancer that could serve for preclinical studies evaluating locoregional therapies.

Augmented fluoroscopy guided transbronchial pulmonary microwave ablation using a steerable sheath.

Background: Transbronchial microwave ablation (MWA) is a promising novel therapy. Despite advances in bronchoscopy and virtual navigation, real time image guidance of probe delivery is lacking, and distal maneuverability is limited. Cone-beam computed tomography (CBCT) based augmented fluoroscopy guidance using steerable sheaths may help overcome these shortcomings.