Publications by authors named "Ahmed S Abdel-Samea"
Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential. This review provides a comprehensive overview of recent advances in the evaluation of indole-based compounds in the last five years, highlighting their roles in cancer treatment, infectious disease management, anti-inflammatory therapies, metabolic disorder interventions, and neurodegenerative disease management. Indole derivatives have shown significant efficacy in targeting diverse biological pathways, making them valuable scaffolds in designing new drugs.
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- - A new series of thiazole-based chalcones was tested for anticancer properties, showing effective inhibition of cancer cell growth, particularly in Ovar-3 and MDA-MB-468 cells, at concentrations between 1.55 and 2.95 μM.
- - One compound notably inhibited tubulin polymerization with an IC value of 7.78 μM, which is less effective than the reference drug Combretastatin-A4 (CA-4) at 4.93 μM.
- - Molecular docking studies indicated that these compounds effectively bind to the same site on tubulin as CA-4, along with predictions suggesting they have good oral bioavailability and potential as chemotherapy drugs.