Bioactivity of silverleaf nightshade (Solanum elaeagnifolium Cav.) berries parts against Galleria mellonella and Erwinia carotovora and LC-MS chemical profile of its potential extract.

Natural products received much attention as an environmentally beneficial solution for pest management. Therefore, the extracts of invasive silverleaf nightshade (Solanum elaeagnifolium Cav.) weeds using their berries parts (seeds, peels and mucilage) supported by bioassay-guided fractionation were tested against both the greater wax moth (Galleria mellonella) and Erwinia carotovora pv.

Correction: New cyclic glycolipids from promote MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and mitotic Mps1/TTK inhibition.

[This corrects the article DOI: 10.1039/D3RA01793A.].

stem bark extract ameliorates obesity, hyperlipidemia, and insulin resistance in a rat model of high fat diet-induced obesity.

Background And Aim: () is an imperative plant with many medicinal uses. The current study aimed to investigate the protective effects of the stem bark of and its fractions in a high fat diet (HFD) rat model.

Experimental Procedure: Seventy-two male albino rats were randomly divided into 9 groups, 8 rats per each.

New cyclic glycolipids from promote MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and mitotic Mps1/TTK inhibition.

anticancer screening of Forssk. aerial parts (Caryophyllaceae) showed that the -hexane fraction was a highly effective fraction against breast carcinoma cell lines (MCF-7) with IC = 15.5 μg mL.

Targeting Natural Plant Metabolites for Hunting SARS-CoV-2 Omicron BA.1 Variant Inhibitors: Extraction, Molecular Docking, Molecular Dynamics, and Physicochemical Properties Study.

(1) Background: SARS-CoV-2 Omicron BA.1 is the most common variation found in most countries and is responsible for 99% of cases in the United States. To overcome this challenge, there is an urgent need to discover effective inhibitors to prevent the emerging BA.

Conducting the RBD of SARS-CoV-2 Omicron Variant with Phytoconstituents from to Repudiate the Binding of Spike Glycoprotein Using Computational Molecular Search and Simulation Approach.

(1) Background: Natural constituents are still a preferred route for counteracting the outbreak of COVID-19. Essentially, flavonoids have been found to be among the most promising molecules identified as coronavirus inhibitors. Recently, a new SARS-CoV-2 B.

Chemical constituents from and their evaluation as potential antiviral agents against SARS-CoV-2.

Wild plants growing in the Egyptian deserts are facing abiotic stress, which can lead to interesting & safe natural products possessing potential chemical profiles. Consequently, our study was designed to assess the phytochemical composition of the aerial parts of (family Plumbaginaceae) growing wild in Egypt for the first time. In addition, screening and molecular dynamic simulation of all isolated phytoconstituents were run against the main protease (M) and spike glycoprotein SARS-CoV-2 targets which displayed a crucial role in the replication of this virus.

Perioperative total intravenous anesthesia in a child with Walker-Warburg syndrome: A case report.

Purpose: Walker-Warburg syndrome is a rare autosomal recessive congenital muscular dystrophy presenting with hydrocephalus, type II lissencephaly, cerebellar malformation, and ocular anomalies. Here, we describe the use of perioperative total intravenous anesthesia in a pediatric patient with Walker-Walburg syndrome.

Clinical Features: A 2-month-old girl with Walker-Walburg syndrome was admitted for urgent ventriculoperitoneal shunt insertion.

Validation of Antidiabetic Potential of Gymnocarpos decandrus Forssk.

Forssk. is a well-known grazing wild plant. This study targets scientific validation of its claimed antidiabetic activity and exploring its bioactive metabolites.

A new cycloartane triterpene and other phytoconstituents from the aerial parts of .

New cycloartane-type triterpene 23 /-3-hydroxycycloart-24-ene-23-methyl ether (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of L. (Euphorbiaceae). The known compounds (-) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids.

Global metabolic changes induced by arbuscular mycorrhizal fungi in oregano plants grown under ambient and elevated levels of atmospheric CO.

Symbiotic plant-microorganisms interaction is a promising approach to avoid the environmental hazards of synthetic fertilizers and pesticides. Among these, arbuscular mycorrhizal fungi (AMF) are known to improve the growth and quality of many plant species; however the detailed metabolic mechanisms behind such beneficial effects are far from complete. Further, elevated levels of atmospheric CO (eCO) could affect such AMF-plant association.

trachylobane-3-hydroperoxide, a new diterpene from the root bark of (Fam.; Euphorbiaceae).

New trachylobane-3-hydroperoxide together with four known compounds, ricinine , trimethoxy ellagic acid , dimethoxy ellagic acid and aleurotolic acid were isolated from the methylene chloride fraction of the root bark of . The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, H NMR, C NMR, HSQC, HMBC, H-H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. trachylobane-3-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC values of 24.

Ethnobotanical investigation on medicinal plants in Algoz area (South Kordofan), Sudan.

Background: The inhabitants of western Sudan use traditional medicine for the treatment of various ailments due to lack of medical doctors and unaffordable prices of pharmaceutical products. The present study is the first documentation of the traditional plant knowledge on medicinal uses of plants by healers in Algoz (South Kordofan), Sudan.

Method: Ethnobotanical data were collected over a period from March to November 2015 using semi-structured interviews with 30 healers (24 male and 6 female) living in the investigated area.

A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca.

Isolation of flavonoids from the aerial parts of Taverniera aegyptiaca Bioss. (Fabaceae) led to identification of one new flavonol glycoside, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (1), along with eleven compounds, which previously have not been isolated from this plant quercetin-3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside] (2), isorhamnetin-3-O-α-l-arabinopyranoside (3), quercetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (4), isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (7), isorhamnetin 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside] (8), isorhamnetin 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside] (9), kaempferol 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside] (10), isorhamnetin (11), 4,4'-dihydroxy-2'-methoxychalcone (12), formononetin (13) and calycosin (15)] and some compounds already known from this plant [quercetin-3-O-robinobioside (5), isorhamnetin-3-O-robinobioside (6), afrormosin (14) and odoratin (16)].

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula.

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis.